Cargando…

Factors Important to the Prioritization and Development of Successful Topical Microbicides for HIV-1

Significant advancements in topical microbicide development have occurred since the prevention strategy was first described as a means to inhibit the sexual transmission of HIV-1. The lack of clinical efficacy of the first generation microbicide products has focused development attention on specific...

Descripción completa

Detalles Bibliográficos
Autores principales:	Buckheit, Karen W., Buckheit, Robert W.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi Publishing Corporation 2012
Materias:	Review Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3403474/ https://www.ncbi.nlm.nih.gov/pubmed/22848826 http://dx.doi.org/10.1155/2012/781305

Ejemplares similares

The Continuing Evolution of HIV-1 Therapy: Identification and Development of Novel Antiretroviral Agents Targeting Viral and Cellular Targets
por: Hartman, Tracy L., et al.
Publicado: (2012)

In Vitro and Ex Vivo Evaluations on Transdermal Delivery of the HIV Inhibitor IQP-0410
por: Ham, Anthony S., et al.
Publicado: (2013)

Primary CD8(+) T cells from elite suppressors effectively eliminate non-productively HIV-1 infected resting and activated CD4(+) T cells
por: Buckheit, Robert W, et al.
Publicado: (2013)

Novel preclinical models of topical PrEP pharmacodynamics provide rationale for combination of drugs with complementary properties
por: Mesquita, Pedro MM, et al.
Publicado: (2013)

Engineering soya bean seeds as a scalable platform to produce cyanovirin‐N, a non‐ARV microbicide against HIV
por: O'Keefe, Barry R., et al.
Publicado: (2015)

CD8(+) T cells from HLA-B*57 elite suppressors effectively suppress replication of HIV-1 escape mutants
por: Pohlmeyer, Christopher W, et al.
Publicado: (2013)

Development of a live topical microbicide for women
por: Xu, Qiang, et al.
Publicado: (2006)

Microbicides for HIV prevention
por: Ramjee, Gita
Publicado: (2011)

Entry inhibitors as topical microbicides to prevent HIV-1 sexual transmission
por: Moore, John P
Publicado: (2006)

Topical microbicides to prevent the transmission of HIV: formulation gaps and challenges
por: Turpin, Jim A.
Publicado: (2011)

Can a Topical Microbicide Prevent Rectal HIV Transmission?
por: Hladik, Florian, et al.
Publicado: (2008)

Which Topical Microbicides for Blocking HIV-1 Transmission Will Work in the Real World?
por: Klasse, Per Johan, et al.
Publicado: (2006)

Punica granatum (Pomegranate) juice provides an HIV-1 entry inhibitor and candidate topical microbicide
por: Neurath, A Robert, et al.
Publicado: (2004)

Green-to-red photoconvertible fluorescent proteins: tracking cell and protein dynamics on standard wide-field mercury arc-based microscopes
por: Baker, Susan M, et al.
Publicado: (2010)

The Promise of Intravaginal Rings for Prevention: User Perceptions of Biomechanical Properties and Implications for Prevention Product Development
por: Morrow Guthrie, Kate, et al.
Publicado: (2015)

Compartmentalized Replication of R5 T Cell-Tropic HIV-1 in the Central Nervous System Early in the Course of Infection
por: Sturdevant, Christa Buckheit, et al.
Publicado: (2015)

Baseline and time‐updated factors in preclinical development of anionic dendrimers as successful anti‐HIV‐1 vaginal microbicides
por: Rodríguez‐Izquierdo, Ignacio, et al.
Publicado: (2022)

Vaginal rings for delivery of HIV microbicides
por: Malcolm, R Karl, et al.
Publicado: (2012)

Microbicides and HIV: A Review and an update
por: Naswa, Smriti, et al.
Publicado: (2012)

Novel Topical Microbicides Through Combinatorial Strategies
por: Arora, Anubhav, et al.
Publicado: (2010)

The Development of Vaginal Microbicides for the Prevention of HIV Transmission
por: Weber, Jonathan, et al.
Publicado: (2005)

Host Factors Dictate Control of Viral Replication in two HIV-1 Controller/Chronic Progressor Transmission Pairs
por: Buckheit, Robert W., et al.
Publicado: (2012)

Algal Lectins as Potential HIV Microbicide Candidates
por: Huskens, Dana, et al.
Publicado: (2012)

Microbicides: a new hope for HIV prevention
por: Nutan,, et al.
Publicado: (2011)

Microbicides for the Treatment of Sexually Transmitted HIV Infections
por: Singh, Onkar, et al.
Publicado: (2014)

HIV and HCV Activate the Inflammasome in Monocytes and Macrophages via Endosomal Toll-Like Receptors without Induction of Type 1 Interferon
por: Chattergoon, Michael A., et al.
Publicado: (2014)

Live microbial microbicides for HIV
por: Hamer, Dean, et al.
Publicado: (2006)

Microbicides & their implications in HIV prevention
por: Karim, Salim S. Abdool, et al.
Publicado: (2010)

Development of HIV-1 Rectal-Specific Microbicides and Colonic Tissue Evaluation
por: Dezzutti, Charlene S., et al.
Publicado: (2014)

Update on microbicide research and development-seeking new HIV prevention tools for women
por: Mertenskoetter, T, et al.
Publicado: (2011)

Development of a CCR5-tropic HIV-1 fusion inhibition assay amenable to high-throughput screening for topical microbicides
por: Beer, B, et al.
Publicado: (2006)

Multivariable analysis to determine if HIV-1 Tat dicysteine motif is associated with neurodevelopmental delay in HIV-infected children in Malawi
por: Dara, Jasmeen, et al.
Publicado: (2015)

Optimizing HIV prevention for women: a review of evidence from microbicide studies and considerations for gender-sensitive microbicide introduction
por: Doggett, Elizabeth G, et al.
Publicado: (2015)

Nanotechnology Applications to HIV Vaccines and Microbicides
por: Boyapalle, Sandhya, et al.
Publicado: (2012)

Development and in vitro evaluation of chloroquine gels as microbicides against HIV-1 infection
por: Brouwers, Joachim, et al.
Publicado: (2008)

Venous Thromboembolism Prophylaxis in Underweight Hospitalized Patients
por: Buckheit, Douglas, et al.
Publicado: (2021)

Microbicides Development Programme: design of a phase III trial to measure the efficacy of the vaginal microbicide PRO 2000/5 for HIV prevention
por: Nunn, Andrew, et al.
Publicado: (2009)

Preclinical evaluation of lime juice as a topical microbicide candidate
por: Fletcher, Patricia S, et al.
Publicado: (2008)

Role of seminal plasma in the anti-HIV-1 activity of candidate microbicides
por: Neurath, A Robert, et al.
Publicado: (2006)

Blocking HIV-1 transmission in the female reproductive tract: from microbicide development to exploring local antiviral responses
por: Eid, Sahar G, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_pjscapml1j17j1e2dasocietf3