The role of mammalian poly(A)-binding proteins in co-ordinating mRNA turnover

The function of cytoplasmic PABPs [poly(A)-binding proteins] in promoting mRNA translation has been intensively studied. However, PABPs also have less clearly defined functions in mRNA turnover including roles in default deadenylation, a major rate-limiting step in mRNA decay, as well as roles in th...

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Detalles Bibliográficos
Autores principales: Brook, Matthew, Gray, Nicola K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2012
Materias:
Independent Meeting
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3403503/
https://www.ncbi.nlm.nih.gov/pubmed/22817748
http://dx.doi.org/10.1042/BST20120100
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author Brook, Matthew
Gray, Nicola K.
author_facet Brook, Matthew
Gray, Nicola K.
author_sort Brook, Matthew
collection PubMed
description The function of cytoplasmic PABPs [poly(A)-binding proteins] in promoting mRNA translation has been intensively studied. However, PABPs also have less clearly defined functions in mRNA turnover including roles in default deadenylation, a major rate-limiting step in mRNA decay, as well as roles in the regulation of mRNA turnover by cis-acting control elements and in the detection of aberrant mRNA transcripts. In the present paper, we review our current understanding of the complex roles of PABP1 in mRNA turnover, focusing on recent progress in mammals and highlighting some of the major questions that remain to be addressed.
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spelling pubmed-34035032012-08-06 The role of mammalian poly(A)-binding proteins in co-ordinating mRNA turnover Brook, Matthew Gray, Nicola K. Biochem Soc Trans Independent Meeting The function of cytoplasmic PABPs [poly(A)-binding proteins] in promoting mRNA translation has been intensively studied. However, PABPs also have less clearly defined functions in mRNA turnover including roles in default deadenylation, a major rate-limiting step in mRNA decay, as well as roles in the regulation of mRNA turnover by cis-acting control elements and in the detection of aberrant mRNA transcripts. In the present paper, we review our current understanding of the complex roles of PABP1 in mRNA turnover, focusing on recent progress in mammals and highlighting some of the major questions that remain to be addressed. Portland Press Ltd. 2012-07-20 2012-08-01 /pmc/articles/PMC3403503/ /pubmed/22817748 http://dx.doi.org/10.1042/BST20120100 Text en © 2012 The Author(s) The author(s) has paid for this article to be freely available under the terms of the Creative Commons Attribution Non-Commercial Licence (http://creativecommons.org/licenses/by-nc/2.5/) which permits unrestricted non-commercial use, distribution and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/licenses/by-nc/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Independent Meeting
Brook, Matthew
Gray, Nicola K.
The role of mammalian poly(A)-binding proteins in co-ordinating mRNA turnover
title The role of mammalian poly(A)-binding proteins in co-ordinating mRNA turnover
title_full The role of mammalian poly(A)-binding proteins in co-ordinating mRNA turnover
title_fullStr The role of mammalian poly(A)-binding proteins in co-ordinating mRNA turnover
title_full_unstemmed The role of mammalian poly(A)-binding proteins in co-ordinating mRNA turnover
title_short The role of mammalian poly(A)-binding proteins in co-ordinating mRNA turnover
title_sort role of mammalian poly(a)-binding proteins in co-ordinating mrna turnover
topic Independent Meeting
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3403503/
https://www.ncbi.nlm.nih.gov/pubmed/22817748
http://dx.doi.org/10.1042/BST20120100
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