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Dexmedetomidine versus Remifentanil for Sedation during Awake Fiberoptic Intubation
This study compared remifentanil and dexmedetomidine as awake fiberoptic intubation (AFOI) anesthetics. Thirty-four adult ASA I-III patients were enrolled in a double-blinded randomized pilot study to receive remifentanil (REM) or dexmedetomidine (DEX) for sedation during AFOI (nasal and oral). Thir...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3403510/ https://www.ncbi.nlm.nih.gov/pubmed/22844277 http://dx.doi.org/10.1155/2012/753107 |
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author | Cattano, Davide Lam, Nicholas C. Ferrario, Lara Seitan, Carmen Vahdat, Kash Wilcox, Darrell W. Hagberg, Carin A. |
author_facet | Cattano, Davide Lam, Nicholas C. Ferrario, Lara Seitan, Carmen Vahdat, Kash Wilcox, Darrell W. Hagberg, Carin A. |
author_sort | Cattano, Davide |
collection | PubMed |
description | This study compared remifentanil and dexmedetomidine as awake fiberoptic intubation (AFOI) anesthetics. Thirty-four adult ASA I-III patients were enrolled in a double-blinded randomized pilot study to receive remifentanil (REM) or dexmedetomidine (DEX) for sedation during AFOI (nasal and oral). Thirty patients completed the study and received 2 mg midazolam IV and topical anesthesia. The REM group received a loading dose of 0.75 mcg/kg followed by an infusion of 0.075 mcg/kg/min. The DEX group received a loading dose of 0.4 mcg/kg followed by an infusion of 0.7 mcg/kg/hr. Time to sedation, number of intubation attempts, Ramsay sedation scale (RSS) score, bispectral index (BIS), and memory recall were recorded. All thirty patients were successfully intubated by AFOI (22 oral intubations/8 nasal). First attempt success rate with AFOI was higher in the REM group than the DEX group, 72% and 38% (P = 0.02), respectively. The DEX group took longer to attain RSS of ≥3 and to achieve BIS <80, as compared to the REM group. Postloading dose verbal recall was poorer in the DEX group. Dexmedetomidine seems a useful adjunct for patients undergoing AFOI but is dependent on dosage and time. Further studies in the use of dexmedetomidine for AFOI are warranted. |
format | Online Article Text |
id | pubmed-3403510 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-34035102012-07-27 Dexmedetomidine versus Remifentanil for Sedation during Awake Fiberoptic Intubation Cattano, Davide Lam, Nicholas C. Ferrario, Lara Seitan, Carmen Vahdat, Kash Wilcox, Darrell W. Hagberg, Carin A. Anesthesiol Res Pract Clinical Study This study compared remifentanil and dexmedetomidine as awake fiberoptic intubation (AFOI) anesthetics. Thirty-four adult ASA I-III patients were enrolled in a double-blinded randomized pilot study to receive remifentanil (REM) or dexmedetomidine (DEX) for sedation during AFOI (nasal and oral). Thirty patients completed the study and received 2 mg midazolam IV and topical anesthesia. The REM group received a loading dose of 0.75 mcg/kg followed by an infusion of 0.075 mcg/kg/min. The DEX group received a loading dose of 0.4 mcg/kg followed by an infusion of 0.7 mcg/kg/hr. Time to sedation, number of intubation attempts, Ramsay sedation scale (RSS) score, bispectral index (BIS), and memory recall were recorded. All thirty patients were successfully intubated by AFOI (22 oral intubations/8 nasal). First attempt success rate with AFOI was higher in the REM group than the DEX group, 72% and 38% (P = 0.02), respectively. The DEX group took longer to attain RSS of ≥3 and to achieve BIS <80, as compared to the REM group. Postloading dose verbal recall was poorer in the DEX group. Dexmedetomidine seems a useful adjunct for patients undergoing AFOI but is dependent on dosage and time. Further studies in the use of dexmedetomidine for AFOI are warranted. Hindawi Publishing Corporation 2012 2012-07-16 /pmc/articles/PMC3403510/ /pubmed/22844277 http://dx.doi.org/10.1155/2012/753107 Text en Copyright © 2012 Davide Cattano et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Clinical Study Cattano, Davide Lam, Nicholas C. Ferrario, Lara Seitan, Carmen Vahdat, Kash Wilcox, Darrell W. Hagberg, Carin A. Dexmedetomidine versus Remifentanil for Sedation during Awake Fiberoptic Intubation |
title | Dexmedetomidine versus Remifentanil for Sedation during Awake Fiberoptic Intubation |
title_full | Dexmedetomidine versus Remifentanil for Sedation during Awake Fiberoptic Intubation |
title_fullStr | Dexmedetomidine versus Remifentanil for Sedation during Awake Fiberoptic Intubation |
title_full_unstemmed | Dexmedetomidine versus Remifentanil for Sedation during Awake Fiberoptic Intubation |
title_short | Dexmedetomidine versus Remifentanil for Sedation during Awake Fiberoptic Intubation |
title_sort | dexmedetomidine versus remifentanil for sedation during awake fiberoptic intubation |
topic | Clinical Study |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3403510/ https://www.ncbi.nlm.nih.gov/pubmed/22844277 http://dx.doi.org/10.1155/2012/753107 |
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