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Emerging Glycolysis Targeting and Drug Discovery from Chinese Medicine in Cancer Therapy

Molecular-targeted therapy has been developed for cancer chemoprevention and treatment. Cancer cells have different metabolic properties from normal cells. Normal cells mostly rely upon the process of mitochondrial oxidative phosphorylation to produce energy whereas cancer cells have developed an al...

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Detalles Bibliográficos
Autores principales: Wang, Zhiyu, Wang, Neng, Chen, Jianping, Shen, Jiangang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3403522/
https://www.ncbi.nlm.nih.gov/pubmed/22844340
http://dx.doi.org/10.1155/2012/873175
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author Wang, Zhiyu
Wang, Neng
Chen, Jianping
Shen, Jiangang
author_facet Wang, Zhiyu
Wang, Neng
Chen, Jianping
Shen, Jiangang
author_sort Wang, Zhiyu
collection PubMed
description Molecular-targeted therapy has been developed for cancer chemoprevention and treatment. Cancer cells have different metabolic properties from normal cells. Normal cells mostly rely upon the process of mitochondrial oxidative phosphorylation to produce energy whereas cancer cells have developed an altered metabolism that allows them to sustain higher proliferation rates. Cancer cells could predominantly produce energy by glycolysis even in the presence of oxygen. This alternative metabolic characteristic is known as the “Warburg Effect.” Although the exact mechanisms underlying the Warburg effect are unclear, recent progress indicates that glycolytic pathway of cancer cells could be a critical target for drug discovery. With a long history in cancer treatment, traditional Chinese medicine (TCM) is recognized as a valuable source for seeking bioactive anticancer compounds. A great progress has been made to identify active compounds from herbal medicine targeting on glycolysis for cancer treatment. Herein, we provide an overall picture of the current understanding of the molecular targets in the cancer glycolytic pathway and reviewed active compounds from Chinese herbal medicine with the potentials to inhibit the metabolic targets for cancer treatment. Combination of TCM with conventional therapies will provide an attractive strategy for improving clinical outcome in cancer treatment.
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spelling pubmed-34035222012-07-27 Emerging Glycolysis Targeting and Drug Discovery from Chinese Medicine in Cancer Therapy Wang, Zhiyu Wang, Neng Chen, Jianping Shen, Jiangang Evid Based Complement Alternat Med Review Article Molecular-targeted therapy has been developed for cancer chemoprevention and treatment. Cancer cells have different metabolic properties from normal cells. Normal cells mostly rely upon the process of mitochondrial oxidative phosphorylation to produce energy whereas cancer cells have developed an altered metabolism that allows them to sustain higher proliferation rates. Cancer cells could predominantly produce energy by glycolysis even in the presence of oxygen. This alternative metabolic characteristic is known as the “Warburg Effect.” Although the exact mechanisms underlying the Warburg effect are unclear, recent progress indicates that glycolytic pathway of cancer cells could be a critical target for drug discovery. With a long history in cancer treatment, traditional Chinese medicine (TCM) is recognized as a valuable source for seeking bioactive anticancer compounds. A great progress has been made to identify active compounds from herbal medicine targeting on glycolysis for cancer treatment. Herein, we provide an overall picture of the current understanding of the molecular targets in the cancer glycolytic pathway and reviewed active compounds from Chinese herbal medicine with the potentials to inhibit the metabolic targets for cancer treatment. Combination of TCM with conventional therapies will provide an attractive strategy for improving clinical outcome in cancer treatment. Hindawi Publishing Corporation 2012 2012-07-12 /pmc/articles/PMC3403522/ /pubmed/22844340 http://dx.doi.org/10.1155/2012/873175 Text en Copyright © 2012 Zhiyu Wang et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Wang, Zhiyu
Wang, Neng
Chen, Jianping
Shen, Jiangang
Emerging Glycolysis Targeting and Drug Discovery from Chinese Medicine in Cancer Therapy
title Emerging Glycolysis Targeting and Drug Discovery from Chinese Medicine in Cancer Therapy
title_full Emerging Glycolysis Targeting and Drug Discovery from Chinese Medicine in Cancer Therapy
title_fullStr Emerging Glycolysis Targeting and Drug Discovery from Chinese Medicine in Cancer Therapy
title_full_unstemmed Emerging Glycolysis Targeting and Drug Discovery from Chinese Medicine in Cancer Therapy
title_short Emerging Glycolysis Targeting and Drug Discovery from Chinese Medicine in Cancer Therapy
title_sort emerging glycolysis targeting and drug discovery from chinese medicine in cancer therapy
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3403522/
https://www.ncbi.nlm.nih.gov/pubmed/22844340
http://dx.doi.org/10.1155/2012/873175
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