Cargando…
Ferulic Acid, an Angelica sinensis-Derived Polyphenol, Slows the Progression of Membranous Nephropathy in a Mouse Model
Membranous nephropathy (MN) is a leading cause of adult nephrotic syndrome but lacks adequate treatment. Different extracts of Angelica sinensis (AS) and one of its active compounds, ferulic acid (FA), were used to evaluate the therapeutic effects in a MN mouse model. The MN model was grouped into t...
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2012
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3403610/ https://www.ncbi.nlm.nih.gov/pubmed/22844329 http://dx.doi.org/10.1155/2012/161235 |
_version_ | 1782238912217874432 |
---|---|
author | Cheng, Chao-Wen Chang, Wen-Liang Chang, Li-Cheng Wu, Chia-Chao Lin, Yuh-Feng Chen, Jin-Shuen |
author_facet | Cheng, Chao-Wen Chang, Wen-Liang Chang, Li-Cheng Wu, Chia-Chao Lin, Yuh-Feng Chen, Jin-Shuen |
author_sort | Cheng, Chao-Wen |
collection | PubMed |
description | Membranous nephropathy (MN) is a leading cause of adult nephrotic syndrome but lacks adequate treatment. Different extracts of Angelica sinensis (AS) and one of its active compounds, ferulic acid (FA), were used to evaluate the therapeutic effects in a MN mouse model. The MN model was grouped into three subgroups: no treatment (N-T), treatment at induction of MN (Pre-T), and treatment after full-blown MN (Post-T). The results showed that the methanol (ME) layer of AS extract exhibited a therapeutic effect on MN-induced proteinuria. The ME layer-enriched compound, FA, improved the hypoalbuminemia, hyperlipidemia, and proteinuria in both Pre-T and Post-T groups. Ferulic acid also reduced the formation of oxidative protein products and increased the synthesis of antioxidant enzymes in groups Pre-T and Post-T. Regarding angiogenesis factors, the antiangiogenic factors in renal glomeruli were increased in group N-T, but, after FA treatment, only one of the antiangiogenic factors, thrombospondin-1, showed a significant decrease. Furthermore, the expression of Th2 predominant showed significant decrease in both Pre-T and Post-T groups when compared to that of N-T group. In summary, FA retarded the progression of MN, and the mechanisms involved the regulation of oxidative stresses, angiogenic and antiangiogenic factors, and attenuation of Th2 response. |
format | Online Article Text |
id | pubmed-3403610 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-34036102012-07-27 Ferulic Acid, an Angelica sinensis-Derived Polyphenol, Slows the Progression of Membranous Nephropathy in a Mouse Model Cheng, Chao-Wen Chang, Wen-Liang Chang, Li-Cheng Wu, Chia-Chao Lin, Yuh-Feng Chen, Jin-Shuen Evid Based Complement Alternat Med Research Article Membranous nephropathy (MN) is a leading cause of adult nephrotic syndrome but lacks adequate treatment. Different extracts of Angelica sinensis (AS) and one of its active compounds, ferulic acid (FA), were used to evaluate the therapeutic effects in a MN mouse model. The MN model was grouped into three subgroups: no treatment (N-T), treatment at induction of MN (Pre-T), and treatment after full-blown MN (Post-T). The results showed that the methanol (ME) layer of AS extract exhibited a therapeutic effect on MN-induced proteinuria. The ME layer-enriched compound, FA, improved the hypoalbuminemia, hyperlipidemia, and proteinuria in both Pre-T and Post-T groups. Ferulic acid also reduced the formation of oxidative protein products and increased the synthesis of antioxidant enzymes in groups Pre-T and Post-T. Regarding angiogenesis factors, the antiangiogenic factors in renal glomeruli were increased in group N-T, but, after FA treatment, only one of the antiangiogenic factors, thrombospondin-1, showed a significant decrease. Furthermore, the expression of Th2 predominant showed significant decrease in both Pre-T and Post-T groups when compared to that of N-T group. In summary, FA retarded the progression of MN, and the mechanisms involved the regulation of oxidative stresses, angiogenic and antiangiogenic factors, and attenuation of Th2 response. Hindawi Publishing Corporation 2012 2012-07-11 /pmc/articles/PMC3403610/ /pubmed/22844329 http://dx.doi.org/10.1155/2012/161235 Text en Copyright © 2012 Chao-Wen Cheng et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Cheng, Chao-Wen Chang, Wen-Liang Chang, Li-Cheng Wu, Chia-Chao Lin, Yuh-Feng Chen, Jin-Shuen Ferulic Acid, an Angelica sinensis-Derived Polyphenol, Slows the Progression of Membranous Nephropathy in a Mouse Model |
title | Ferulic Acid, an Angelica sinensis-Derived Polyphenol, Slows the Progression of Membranous Nephropathy in a Mouse Model |
title_full | Ferulic Acid, an Angelica sinensis-Derived Polyphenol, Slows the Progression of Membranous Nephropathy in a Mouse Model |
title_fullStr | Ferulic Acid, an Angelica sinensis-Derived Polyphenol, Slows the Progression of Membranous Nephropathy in a Mouse Model |
title_full_unstemmed | Ferulic Acid, an Angelica sinensis-Derived Polyphenol, Slows the Progression of Membranous Nephropathy in a Mouse Model |
title_short | Ferulic Acid, an Angelica sinensis-Derived Polyphenol, Slows the Progression of Membranous Nephropathy in a Mouse Model |
title_sort | ferulic acid, an angelica sinensis-derived polyphenol, slows the progression of membranous nephropathy in a mouse model |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3403610/ https://www.ncbi.nlm.nih.gov/pubmed/22844329 http://dx.doi.org/10.1155/2012/161235 |
work_keys_str_mv | AT chengchaowen ferulicacidanangelicasinensisderivedpolyphenolslowstheprogressionofmembranousnephropathyinamousemodel AT changwenliang ferulicacidanangelicasinensisderivedpolyphenolslowstheprogressionofmembranousnephropathyinamousemodel AT changlicheng ferulicacidanangelicasinensisderivedpolyphenolslowstheprogressionofmembranousnephropathyinamousemodel AT wuchiachao ferulicacidanangelicasinensisderivedpolyphenolslowstheprogressionofmembranousnephropathyinamousemodel AT linyuhfeng ferulicacidanangelicasinensisderivedpolyphenolslowstheprogressionofmembranousnephropathyinamousemodel AT chenjinshuen ferulicacidanangelicasinensisderivedpolyphenolslowstheprogressionofmembranousnephropathyinamousemodel |