Early intervention with a small molecule inhibitor for tumor nefosis factor-α prevents cognitive deficits in a triple transgenic mouse model of Alzheimer’s disease

BACKGROUND: Chronic neuroinflammation is an important component of Alzheimer’s disease and could contribute to neuronal dysfunction, injury and loss that lead to disease progression. Multiple clinical studies implicate tumor necrosis factor-α as an inflammatory mediator of neurodegeneration in patie...

Descripción completa

Detalles Bibliográficos
Autores principales: Gabbita, S Prasad, Srivastava, Minu K, Eslami, Pirooz, Johnson, Ming F, Kobritz, Naomi K, Tweedie, David, Greig, Nigel H, Zemlan, Frank P, Sharma, Sherven P, Harris-White, Marni E
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3403851/
https://www.ncbi.nlm.nih.gov/pubmed/22632257
http://dx.doi.org/10.1186/1742-2094-9-99

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3403851/
https://www.ncbi.nlm.nih.gov/pubmed/22632257
http://dx.doi.org/10.1186/1742-2094-9-99

Ejemplares similares