Cargando…

Early intervention with a small molecule inhibitor for tumor nefosis factor-α prevents cognitive deficits in a triple transgenic mouse model of Alzheimer’s disease

BACKGROUND: Chronic neuroinflammation is an important component of Alzheimer’s disease and could contribute to neuronal dysfunction, injury and loss that lead to disease progression. Multiple clinical studies implicate tumor necrosis factor-α as an inflammatory mediator of neurodegeneration in patie...

Descripción completa

Detalles Bibliográficos
Autores principales:	Gabbita, S Prasad, Srivastava, Minu K, Eslami, Pirooz, Johnson, Ming F, Kobritz, Naomi K, Tweedie, David, Greig, Nigel H, Zemlan, Frank P, Sharma, Sherven P, Harris-White, Marni E
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2012
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3403851/ https://www.ncbi.nlm.nih.gov/pubmed/22632257 http://dx.doi.org/10.1186/1742-2094-9-99

Ejemplares similares

Oral TNFα Modulation Alters Neutrophil Infiltration, Improves Cognition and Diminishes Tau and Amyloid Pathology in the 3xTgAD Mouse Model
por: Gabbita, S. Prasad, et al.
Publicado: (2015)

Targeting MDSCs enhance therapeutic vaccination responses against lung cancer
por: Srivastava, Minu K., et al.
Publicado: (2012)

De Novo Generation of Murine and Human MADR Recipient Cell Lines for Locus-Specific, Stable Integration of Transgenic Elements
por: Ayala-Sarmiento, Alberto E., et al.
Publicado: (2020)

TNF-α protein synthesis inhibitor restores neuronal function and reverses cognitive deficits induced by chronic neuroinflammation
por: Belarbi, Karim, et al.
Publicado: (2012)

Correction: Myeloid Suppressor Cell Depletion Augments Antitumor Activity in Lung Cancer
por: Srivastava, Minu K., et al.
Publicado: (2012)

Myeloid Suppressor Cell Depletion Augments Antitumor Activity in Lung Cancer
por: Srivastava, Minu K., et al.
Publicado: (2012)

Targeting myeloid-derived suppressor cells augments antitumor activity against lung cancer
por: Srivastava, Minu K, et al.
Publicado: (2012)

A Humanin Derivative Reduces Amyloid Beta Accumulation and Ameliorates Memory Deficit in Triple Transgenic Mice
por: Niikura, Takako, et al.
Publicado: (2011)

Novel CCL21-Vault Nanocapsule Intratumoral Delivery Inhibits Lung Cancer Growth
por: Kar, Upendra K., et al.
Publicado: (2011)

HGG-43. INTERROGATING THE ROLE OF PEA3 ONCOGENIC TRANSCRIPTION FACTORS IN PEDIATRIC HIGH-GRADE K27M GLIOMAS
por: Park, Hannah, et al.
Publicado: (2021)

Neuroinflammation as a Factor of Neurodegenerative Disease: Thalidomide Analogs as Treatments
por: Jung, Yoo Jin, et al.
Publicado: (2019)

Suppression of Harmaline Tremor by Activation of an Extrasynaptic GABA(A) Receptor: Implications for Essential Tremor
por: Handforth, Adrian, et al.
Publicado: (2018)

Acetylcholinesterase inhibition ameliorates deficits in motivational drive
por: Martinowich, Keri, et al.
Publicado: (2012)

Thalidomide Analogues Suppress Lipopolysaccharide-Induced Synthesis of TNF-α and Nitrite, an Intermediate of Nitric Oxide, in a Cellular Model of Inflammation
por: Tweedie, David, et al.
Publicado: (2011)

Differential responsiveness of MET inhibition in non-small-cell lung cancer with altered CBL
por: Tan, Yi-Hung Carol, et al.
Publicado: (2017)

A Triple-Transgenic Immunotolerant Mouse Model
por: Brenden, Nina, et al.
Publicado: (2013)

3,6’-dithiopomalidomide reduces neural loss, inflammation, behavioral deficits in brain injury and microglial activation
por: Lin, Chih-Tung, et al.
Publicado: (2020)

Vault Nanocapsules as Adjuvants Favor Cell-Mediated over Antibody-Mediated Immune Responses following Immunization of Mice
por: Kar, Upendra K., et al.
Publicado: (2012)

Maternal High-Fat Diet Worsens Memory Deficits in the Triple-Transgenic (3xTgAD) Mouse Model of Alzheimer’s Disease
por: Martin, Sarah A. L., et al.
Publicado: (2014)

A Shortened Barnes Maze Protocol Reveals Memory Deficits at 4-Months of Age in the Triple-Transgenic Mouse Model of Alzheimer's Disease
por: Attar, Aida, et al.
Publicado: (2013)

Bexarotene therapy ameliorates behavioral deficits and induces functional and molecular changes in very-old Triple Transgenic Mice model of Alzheimer´s disease
por: Muñoz-Cabrera, Jonathan Mauricio, et al.
Publicado: (2019)

Isoflurane mediated neuropathological and cognitive impairments in the triple transgenic Alzheimer’s mouse model are associated with hippocampal synaptic deficits in an age-dependent manner
por: Joseph, Donald J., et al.
Publicado: (2019)

Tumor necrosis factor-α synthesis inhibitor 3,6′-dithiothalidomide attenuates markers of inflammation, Alzheimer pathology and behavioral deficits in animal models of neuroinflammation and Alzheimer’s disease
por: Tweedie, David, et al.
Publicado: (2012)

IL-27 inhibits epithelial-mesenchymal transition and angiogenic factor production in a STAT1-dominant pathway in human non-small cell lung cancer
por: Kachroo, Puja, et al.
Publicado: (2013)

Altered Immune Responses in Interleukin 10 Transgenic Mice
por: Hagenbaugh, Amy, et al.
Publicado: (1997)

In Silico and Ex Vivo Analyses of the Inhibitory Action of the Alzheimer Drug Posiphen and Primary Metabolites with Human Acetyl- and Butyrylcholinesterase Enzymes
por: Batool, Sidra, et al.
Publicado: (2022)

Progression of temporal processing deficits in the HIV-1 transgenic rat
por: McLaurin, Kristen A., et al.
Publicado: (2016)

Cornel iridoid glycoside ameliorates cognitive deficits in APP/PS1/tau triple transgenic mice by attenuating amyloid-beta, tau hyperphosphorylation and neurotrophic dysfunction
por: Yang, Cuicui, et al.
Publicado: (2020)

DNA vaccines targeting amyloid-β oligomer ameliorate cognitive deficits of aged APP/PS1/tau triple-transgenic mouse models of Alzheimer’s disease
por: Sha, Sha, et al.
Publicado: (2022)

Peripheral adaptive immunity of the triple transgenic mouse model of Alzheimer’s disease
por: St-Amour, Isabelle, et al.
Publicado: (2019)

Dendritic complexity change in the triple transgenic mouse model of Alzheimer’s disease
por: Zhang, Yu, et al.
Publicado: (2020)

Adult neurogenic deficits in HIV-1 Tg26 transgenic mice
por: Putatunda, Raj, et al.
Publicado: (2018)

Preventive Effect of Quercetin in a Triple Transgenic Alzheimer’s Disease Mice Model
por: Paula, Pérez-Corredor, et al.
Publicado: (2019)

A Novel Triple-Mutant AAV6 Capsid Induces Rapid and Potent Transgene Expression in the Muscle and Respiratory Tract of Mice
por: van Lieshout, Laura P., et al.
Publicado: (2018)

Transgenic rescue of phenotypic deficits in a mouse model of alternating hemiplegia of childhood
por: Kirshenbaum, Greer S., et al.
Publicado: (2015)

Tau is required for progressive synaptic and memory deficits in a transgenic mouse model of α-synucleinopathy
por: Singh, Balvindar, et al.
Publicado: (2019)

Deletion of Irs2 reduces amyloid deposition and rescues behavioural deficits in APP transgenic mice
por: Killick, Richard, et al.
Publicado: (2009)

nAChRs gene expression and neuroinflammation in APPswe/PS1dE9 transgenic mouse
por: D’Angelo, Chiara, et al.
Publicado: (2021)

Exendin-4 Ameliorates Motor Neuron Degeneration in Cellular and Animal Models of Amyotrophic Lateral Sclerosis
por: Li, Yazhou, et al.
Publicado: (2012)

Cognitive Impairments Accompanying Rodent Mild Traumatic Brain Injury Involve p53-Dependent Neuronal Cell Death and Are Ameliorated by the Tetrahydrobenzothiazole PFT-α
por: Rachmany, Lital, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_5bn2q14pq7bdd8un9f6ssp22si