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Ribonucleotide reductase inhibition restores platinum-sensitivity in platinum-resistant ovarian cancer: a Gynecologic Oncology Group Study

BACKGROUND: The potent ribonucleotide reductase (RNR) inhibitor 3-aminopyridine-2-carboxyaldehyde-thiosemicarbazone (3-AP) was tested as a chemosensitizer for restored cisplatin-mediated cytotoxicity in platinum-resistant ovarian cancer. METHODS: Preclinical in vitro platinum-resistant ovarian cance...

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Detalles Bibliográficos
Autores principales:	Kunos, Charles, Radivoyevitch, Tomas, Abdul-Karim, Fadi W, Fanning, James, Abulafia, Ovadia, Bonebrake, Albert J, Usha, Lydia
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2012
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3403898/ https://www.ncbi.nlm.nih.gov/pubmed/22541066 http://dx.doi.org/10.1186/1479-5876-10-79

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