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Is dengue and malaria co-infection more severe than single infections? A retrospective matched-pair study in French Guiana

BACKGROUND: Dengue and malaria are two major arthropod-borne infections in tropical areas, but dual infections were only described for the first time in 2005. Reports of these concomitant infections are scarce and there is no evidence of more severe clinical and biological pictures than single infec...

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Autores principales: Epelboin, Loïc, Hanf, Matthieu, Dussart, Philippe, Ouar-Epelboin, Sihem, Djossou, Félix, Nacher, Mathieu, Carme, Bernard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3403992/
https://www.ncbi.nlm.nih.gov/pubmed/22549018
http://dx.doi.org/10.1186/1475-2875-11-142
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author Epelboin, Loïc
Hanf, Matthieu
Dussart, Philippe
Ouar-Epelboin, Sihem
Djossou, Félix
Nacher, Mathieu
Carme, Bernard
author_facet Epelboin, Loïc
Hanf, Matthieu
Dussart, Philippe
Ouar-Epelboin, Sihem
Djossou, Félix
Nacher, Mathieu
Carme, Bernard
author_sort Epelboin, Loïc
collection PubMed
description BACKGROUND: Dengue and malaria are two major arthropod-borne infections in tropical areas, but dual infections were only described for the first time in 2005. Reports of these concomitant infections are scarce and there is no evidence of more severe clinical and biological pictures than single infections. METHODS: To compare co-infections to dengue alone and malaria alone, a retrospective matched-pair study was conducted between 2004 and 2010 among patients admitted in the emergency department of Cayenne hospital, French Guiana. RESULTS: 104 dengue and malaria co-infection cases were identified during the study period and 208 individuals were matched in two comparison groups: dengue alone and malaria alone. In bivariate analysis, co-infection clinical picture was more severe than separated infections, in particular using the severe malaria WHO criteria. In multivariate analysis, independent factors associated with co-infection versus dengue were: masculine gender, CRP level > 50 mg/L, thrombocytopaenia < 50 10(9)/L, and low haematocrit <36% and independent factors significantly associated with co-infections versus malaria were red cells transfusion, low haematocrit < 36%, thrombocytopaenia < 50 10(9)/L and low Plasmodium parasitic load < 0.001%. CONCLUSIONS: In the present study, dengue and malaria co-infection clinical picture seems to be more severe than single infections in French Guiana, with a greater risk of deep thrombocytopaenia and anaemia.
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spelling pubmed-34039922012-07-25 Is dengue and malaria co-infection more severe than single infections? A retrospective matched-pair study in French Guiana Epelboin, Loïc Hanf, Matthieu Dussart, Philippe Ouar-Epelboin, Sihem Djossou, Félix Nacher, Mathieu Carme, Bernard Malar J Research BACKGROUND: Dengue and malaria are two major arthropod-borne infections in tropical areas, but dual infections were only described for the first time in 2005. Reports of these concomitant infections are scarce and there is no evidence of more severe clinical and biological pictures than single infections. METHODS: To compare co-infections to dengue alone and malaria alone, a retrospective matched-pair study was conducted between 2004 and 2010 among patients admitted in the emergency department of Cayenne hospital, French Guiana. RESULTS: 104 dengue and malaria co-infection cases were identified during the study period and 208 individuals were matched in two comparison groups: dengue alone and malaria alone. In bivariate analysis, co-infection clinical picture was more severe than separated infections, in particular using the severe malaria WHO criteria. In multivariate analysis, independent factors associated with co-infection versus dengue were: masculine gender, CRP level > 50 mg/L, thrombocytopaenia < 50 10(9)/L, and low haematocrit <36% and independent factors significantly associated with co-infections versus malaria were red cells transfusion, low haematocrit < 36%, thrombocytopaenia < 50 10(9)/L and low Plasmodium parasitic load < 0.001%. CONCLUSIONS: In the present study, dengue and malaria co-infection clinical picture seems to be more severe than single infections in French Guiana, with a greater risk of deep thrombocytopaenia and anaemia. BioMed Central 2012-05-01 /pmc/articles/PMC3403992/ /pubmed/22549018 http://dx.doi.org/10.1186/1475-2875-11-142 Text en Copyright ©2012 Epelboin et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research
Epelboin, Loïc
Hanf, Matthieu
Dussart, Philippe
Ouar-Epelboin, Sihem
Djossou, Félix
Nacher, Mathieu
Carme, Bernard
Is dengue and malaria co-infection more severe than single infections? A retrospective matched-pair study in French Guiana
title Is dengue and malaria co-infection more severe than single infections? A retrospective matched-pair study in French Guiana
title_full Is dengue and malaria co-infection more severe than single infections? A retrospective matched-pair study in French Guiana
title_fullStr Is dengue and malaria co-infection more severe than single infections? A retrospective matched-pair study in French Guiana
title_full_unstemmed Is dengue and malaria co-infection more severe than single infections? A retrospective matched-pair study in French Guiana
title_short Is dengue and malaria co-infection more severe than single infections? A retrospective matched-pair study in French Guiana
title_sort is dengue and malaria co-infection more severe than single infections? a retrospective matched-pair study in french guiana
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3403992/
https://www.ncbi.nlm.nih.gov/pubmed/22549018
http://dx.doi.org/10.1186/1475-2875-11-142
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