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CAR/FoxP3-engineered T regulatory cells target the CNS and suppress EAE upon intranasal delivery

BACKGROUND: Multiple sclerosis (MS) is an autoimmune disease of the central nervous system (CNS). In the murine experimental autoimmune encephalomyelitis (EAE) model of MS, T regulatory (Treg) cell therapy has proved to be beneficial, but generation of stable CNS-targeting Tregs needs further develo...

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Detalles Bibliográficos
Autores principales:	Fransson, Moa, Piras, Elena, Burman, Joachim, Nilsson, Berith, Essand, Magnus, Lu, BinFeng, Harris, Robert A, Magnusson, Peetra U, Brittebo, Eva, Loskog, Angelica SI
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2012
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3403996/ https://www.ncbi.nlm.nih.gov/pubmed/22647574 http://dx.doi.org/10.1186/1742-2094-9-112

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