Cargando…

Prognostic Implication of Histological Oligodendroglial Tumor Component: Clinicopathological Analysis of 111 Cases of Malignant Gliomas

The favorable prognosis of high-grade oligodendroglial tumor such as glioblastoma (GBM) with oligodendroglioma component (GBMO) has been suggested; however, the studies which examine the prognostic significance of oligodendroglial tumor were limited. In this study, we performed a histopathology-base...

Descripción completa

Detalles Bibliográficos
Autores principales: Kanno, Hiromi, Nishihara, Hiroshi, Narita, Takuhito, Yamaguchi, Shigeru, Kobayashi, Hiroyuki, Tanino, Mishie, Kimura, Taichi, Terasaka, Shunsuke, Tanaka, Shinya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3404002/
https://www.ncbi.nlm.nih.gov/pubmed/22911839
http://dx.doi.org/10.1371/journal.pone.0041669
_version_ 1782238966738583552
author Kanno, Hiromi
Nishihara, Hiroshi
Narita, Takuhito
Yamaguchi, Shigeru
Kobayashi, Hiroyuki
Tanino, Mishie
Kimura, Taichi
Terasaka, Shunsuke
Tanaka, Shinya
author_facet Kanno, Hiromi
Nishihara, Hiroshi
Narita, Takuhito
Yamaguchi, Shigeru
Kobayashi, Hiroyuki
Tanino, Mishie
Kimura, Taichi
Terasaka, Shunsuke
Tanaka, Shinya
author_sort Kanno, Hiromi
collection PubMed
description The favorable prognosis of high-grade oligodendroglial tumor such as glioblastoma (GBM) with oligodendroglioma component (GBMO) has been suggested; however, the studies which examine the prognostic significance of oligodendroglial tumor were limited. In this study, we performed a histopathology-based reevaluation of 111 cases of high grade gliomas according to the latest World Health Organization (WHO), and compared the clinical outcomes between oligodendroglial tumors and pure astrocytic tumors. The survival analysis revealed that the patients with high grade oligodendroglial tumor including GBMO significantly indicated better prognosis compared to the patients with high grade pure astrocytic tumors (GBM and AA, anaplastic astrocytoma) as expected, and the obtained survival curves were almost identical to those from the patients with conventional Grade III or Grade IV tumors, respectively. Moreover, if the cases of oligodendroglial tumor were histopathologically excluded, the patients with AA exhibited extremely poor prognosis which was similar to that of GBM, suggesting that the histological identification of oligodendroglial tumor component, even partially, prescribe the prognosis of high grade glioma patients. This is the prominent report of retrospective clinicopathological analysis for high-grade gliomas throughout Grade III and IV, especially referring to the prognostic value of histological oligodendroglial tumor component; in addition, our results might offer an alternative aspect for the grading of high-grade astrocytic/oligodendroglial tumors.
format Online
Article
Text
id pubmed-3404002
institution National Center for Biotechnology Information
language English
publishDate 2012
publisher Public Library of Science
record_format MEDLINE/PubMed
spelling pubmed-34040022012-07-30 Prognostic Implication of Histological Oligodendroglial Tumor Component: Clinicopathological Analysis of 111 Cases of Malignant Gliomas Kanno, Hiromi Nishihara, Hiroshi Narita, Takuhito Yamaguchi, Shigeru Kobayashi, Hiroyuki Tanino, Mishie Kimura, Taichi Terasaka, Shunsuke Tanaka, Shinya PLoS One Research Article The favorable prognosis of high-grade oligodendroglial tumor such as glioblastoma (GBM) with oligodendroglioma component (GBMO) has been suggested; however, the studies which examine the prognostic significance of oligodendroglial tumor were limited. In this study, we performed a histopathology-based reevaluation of 111 cases of high grade gliomas according to the latest World Health Organization (WHO), and compared the clinical outcomes between oligodendroglial tumors and pure astrocytic tumors. The survival analysis revealed that the patients with high grade oligodendroglial tumor including GBMO significantly indicated better prognosis compared to the patients with high grade pure astrocytic tumors (GBM and AA, anaplastic astrocytoma) as expected, and the obtained survival curves were almost identical to those from the patients with conventional Grade III or Grade IV tumors, respectively. Moreover, if the cases of oligodendroglial tumor were histopathologically excluded, the patients with AA exhibited extremely poor prognosis which was similar to that of GBM, suggesting that the histological identification of oligodendroglial tumor component, even partially, prescribe the prognosis of high grade glioma patients. This is the prominent report of retrospective clinicopathological analysis for high-grade gliomas throughout Grade III and IV, especially referring to the prognostic value of histological oligodendroglial tumor component; in addition, our results might offer an alternative aspect for the grading of high-grade astrocytic/oligodendroglial tumors. Public Library of Science 2012-07-24 /pmc/articles/PMC3404002/ /pubmed/22911839 http://dx.doi.org/10.1371/journal.pone.0041669 Text en Kanno et al. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Kanno, Hiromi
Nishihara, Hiroshi
Narita, Takuhito
Yamaguchi, Shigeru
Kobayashi, Hiroyuki
Tanino, Mishie
Kimura, Taichi
Terasaka, Shunsuke
Tanaka, Shinya
Prognostic Implication of Histological Oligodendroglial Tumor Component: Clinicopathological Analysis of 111 Cases of Malignant Gliomas
title Prognostic Implication of Histological Oligodendroglial Tumor Component: Clinicopathological Analysis of 111 Cases of Malignant Gliomas
title_full Prognostic Implication of Histological Oligodendroglial Tumor Component: Clinicopathological Analysis of 111 Cases of Malignant Gliomas
title_fullStr Prognostic Implication of Histological Oligodendroglial Tumor Component: Clinicopathological Analysis of 111 Cases of Malignant Gliomas
title_full_unstemmed Prognostic Implication of Histological Oligodendroglial Tumor Component: Clinicopathological Analysis of 111 Cases of Malignant Gliomas
title_short Prognostic Implication of Histological Oligodendroglial Tumor Component: Clinicopathological Analysis of 111 Cases of Malignant Gliomas
title_sort prognostic implication of histological oligodendroglial tumor component: clinicopathological analysis of 111 cases of malignant gliomas
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3404002/
https://www.ncbi.nlm.nih.gov/pubmed/22911839
http://dx.doi.org/10.1371/journal.pone.0041669
work_keys_str_mv AT kannohiromi prognosticimplicationofhistologicaloligodendroglialtumorcomponentclinicopathologicalanalysisof111casesofmalignantgliomas
AT nishiharahiroshi prognosticimplicationofhistologicaloligodendroglialtumorcomponentclinicopathologicalanalysisof111casesofmalignantgliomas
AT naritatakuhito prognosticimplicationofhistologicaloligodendroglialtumorcomponentclinicopathologicalanalysisof111casesofmalignantgliomas
AT yamaguchishigeru prognosticimplicationofhistologicaloligodendroglialtumorcomponentclinicopathologicalanalysisof111casesofmalignantgliomas
AT kobayashihiroyuki prognosticimplicationofhistologicaloligodendroglialtumorcomponentclinicopathologicalanalysisof111casesofmalignantgliomas
AT taninomishie prognosticimplicationofhistologicaloligodendroglialtumorcomponentclinicopathologicalanalysisof111casesofmalignantgliomas
AT kimurataichi prognosticimplicationofhistologicaloligodendroglialtumorcomponentclinicopathologicalanalysisof111casesofmalignantgliomas
AT terasakashunsuke prognosticimplicationofhistologicaloligodendroglialtumorcomponentclinicopathologicalanalysisof111casesofmalignantgliomas
AT tanakashinya prognosticimplicationofhistologicaloligodendroglialtumorcomponentclinicopathologicalanalysisof111casesofmalignantgliomas