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Antitumoral Efficacy of the Protease Inhibitor Gabexate Mesilate in Colon Cancer Cells Harbouring KRAS, BRAF and PIK3CA Mutations

The employment of anti-epidermal growth factor receptor (EGFR) antibodies represents a backbone of the therapeutic options for the treatment of metastatic colorectal cancer (mCRC). However, this therapy is poorly effective or ineffective in unselected patients. Mutations in KRAS, BRAF and PIK3CA gen...

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Detalles Bibliográficos
Autores principales:	Brandi, Giovanni, Tavolari, Simona, De Rosa, Francesco, Di Girolamo, Stefania, Agostini, Valentina, Barbera, Maria Aurelia, Frega, Giorgio, Biasco, Guido
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3404056/ https://www.ncbi.nlm.nih.gov/pubmed/22911782 http://dx.doi.org/10.1371/journal.pone.0041347

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