SNP Calling, Genotype Calling, and Sample Allele Frequency Estimation from New-Generation Sequencing Data

We present a statistical framework for estimation and application of sample allele frequency spectra from New-Generation Sequencing (NGS) data. In this method, we first estimate the allele frequency spectrum using maximum likelihood. In contrast to previous methods, the likelihood function is calcul...

Descripción completa

Detalles Bibliográficos
Autores principales: Nielsen, Rasmus, Korneliussen, Thorfinn, Albrechtsen, Anders, Li, Yingrui, Wang, Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3404070/
https://www.ncbi.nlm.nih.gov/pubmed/22911679
http://dx.doi.org/10.1371/journal.pone.0037558

Ejemplares similares

Ejemplares similares