Cargando…

Vascular Disrupting Agent Drug Classes Differ in Effects on the Cytoskeleton

Vascular disrupting agents (VDAs), anti-cancer drugs that target established tumor blood vessels, fall into two main classes: microtubule targeting drugs, exemplified by combretastatin A4 (CA4), and flavonoids, exemplified by 5,6-dimethylxanthenone-4-acetic acid (DMXAA). Both classes increase permea...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kim, Sujeong, Peshkin, Leonid, Mitchison, Timothy J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3404093/ https://www.ncbi.nlm.nih.gov/pubmed/22848372 http://dx.doi.org/10.1371/journal.pone.0040177

Ejemplares similares

Disruption of the association between drug transporter and actin cytoskeleton abolishes drug resistance in hypertrophic scar
por: Su, Linlin, et al.
Publicado: (2016)

Regulated Actin Cytoskeleton Assembly at Filopodium Tips Controls Their Extension and Retraction
por: Mallavarapu, Aneil, et al.
Publicado: (1999)

Vascular disrupting agents in clinical development
por: Hinnen, P, et al.
Publicado: (2007)

Vascular disrupting agent induced aggregation of gold nanoparticles for photothermally enhanced tumor vascular disruption
por: Hong, Sheng, et al.
Publicado: (2020)

Hemodynamics and the vascular endothelial cytoskeleton
Publicado: (1987)

Vascular aging, the vascular cytoskeleton and aortic stiffness
por: Kajuluri, Lova Prasadareddy, et al.
Publicado: (2021)

Sinularin, an Anti-Cancer Agent Causing Mitochondria-Modulated Apoptosis and Cytoskeleton Disruption in Human Hepatocellular Carcinoma
por: Ko, Chou-Yuan, et al.
Publicado: (2021)

Signaling Mechanisms and Disrupted Cytoskeleton in the Diphenyl Ditelluride Neurotoxicity
por: Pessoa-Pureur, Regina, et al.
Publicado: (2014)

Oxidative stress disrupts the cytoskeleton of spinal motor neurons
por: Chen, Jian, et al.
Publicado: (2022)

Vascular Disrupting Agent Arsenic Trioxide Enhances Thermoradiotherapy of Solid Tumors
por: Griffin, Robert J., et al.
Publicado: (2012)

Induction of chondrogenesis in limb mesenchymal cultures by disruption of the actin cytoskeleton
Publicado: (1984)

Microtubule cytoskeleton-disrupting activity of MWCNTs: applications in cancer treatment
por: Hevia, Lorena García, et al.
Publicado: (2020)

Breast Cancer Selective Disruption of Actin Cytoskeleton by Diallyl Trisulfide
por: Hahm, Eun-Ryeong, et al.
Publicado: (2022)

Growth inhibition associated with disruption of the actin cytoskeleton by Latrunculin A in rhabdomyosarcoma cells
por: Würtemberger, Julia, et al.
Publicado: (2020)

Characterization of the Endothelial Cell Cytoskeleton following HLA Class I Ligation
por: Ziegler, Mary E., et al.
Publicado: (2012)

Evolutionarily Repurposed Networks Reveal the Well-Known Antifungal Drug Thiabendazole to Be a Novel Vascular Disrupting Agent
por: Cha, Hye Ji, et al.
Publicado: (2012)

Two classes of actin microfilaments are associated with the inner cytoskeleton of axons
Publicado: (1988)

The Interactive Effects of Cytoskeleton Disruption and Mitochondria Dysfunction Lead to Reproductive Toxicity Induced by Microcystin-LR
por: Chen, Liang, et al.
Publicado: (2013)

Depletion of the LINC complex disrupts cytoskeleton dynamics and meiotic resumption in mouse oocytes
por: Luo, Yibo, et al.
Publicado: (2016)

Tumor resistance to vascular disrupting agents: mechanisms, imaging, and solutions
por: Liang, Wenjie, et al.
Publicado: (2016)

Vascular disrupting agent DMXAA enhances the antitumor effects generated by therapeutic HPV DNA vaccines
por: Peng, Shiwen, et al.
Publicado: (2011)

Olaquindox disrupts tight junction integrity and cytoskeleton architecture in mouse Sertoli cells
por: Wu, Di, et al.
Publicado: (2017)

Spatial morphological and molecular differences within solid tumors may contribute to the failure of vascular disruptive agent treatments
por: Nguyen, Linh, et al.
Publicado: (2012)

DCE-MRI biomarkers in the clinical evaluation of antiangiogenic and vascular disrupting agents
por: O'Connor, J P B, et al.
Publicado: (2007)

Histamine, a vasoactive agent with vascular disrupting potential, improves tumour response by enhancing local drug delivery
por: Brunstein, F, et al.
Publicado: (2006)

Treatment Effect of a Vascular-Disrupting Agent Dynamically Monitored by DWI: An Animal Experimental Study
por: Huang, Danping, et al.
Publicado: (2021)

Disruption of the actin cytoskeleton after microinjection of proteolytic fragments of alpha-actinin
Publicado: (1991)

Cinnamic acid induces apoptotic cell death and cytoskeleton disruption in human melanoma cells
por: Niero, Evandro Luís de Oliveira, et al.
Publicado: (2013)

Dexamethasone disrupts intercellular junction formation and cytoskeleton organization in human trabecular meshwork cells
por: Zhuo, Ye Hong, et al.
Publicado: (2010)

Effective Rapid Blood Perfusion in Xenopus
por: Jonas-Closs, Rachael A, et al.
Publicado: (2023)

Disrupting actin filaments enhances glucose-stimulated insulin secretion independent of the cortical actin cytoskeleton
por: Polino, Alexander J., et al.
Publicado: (2023)

Calcineurin Signaling Mediates Disruption of the Axon Initial Segment Cytoskeleton after Injury
por: Zhao, Yanan, et al.
Publicado: (2020)

LPA suppresses T cell function by altering the cytoskeleton and disrupting immune synapse formation
por: Kremer, Kimberly N., et al.
Publicado: (2022)

First-in-Class Colchicine-Based Visible Light Photoswitchable Microtubule Dynamics Disrupting Agent
por: Borys, Filip, et al.
Publicado: (2023)

Identification of a distinct class of cytoskeleton-associated mRNAs using microarray technology
por: Brock, Amy, et al.
Publicado: (2003)

Nanomechanics in Monitoring the Effectiveness of Drugs Targeting the Cancer Cell Cytoskeleton
por: Kubiak, Andrzej, et al.
Publicado: (2020)

Quantifying the Evolution of Vascular Barrier Disruption in Advanced Atherosclerosis with Semipermeant Nanoparticle Contrast Agents
por: Zhang, Huiying, et al.
Publicado: (2011)

A Ruthenium(II) Polypyridyl Complex Disrupts Actin Cytoskeleton Assembly and Blocks Cytokinesis
por: Gill, Martin R., et al.
Publicado: (2022)

Evaluation of the antitumor activity of NOV202, a novel microtubule targeting and vascular disrupting agent
por: Rickardson, Linda, et al.
Publicado: (2017)

Molecular mechanisms that enhance synapse stability despite persistent disruption of the spectrin/ankyrin/microtubule cytoskeleton
por: Massaro, Catherine M., et al.
Publicado: (2009)

Cannot write session to /tmp/vufind_sessions/sess_7slpi3j0cco61jtsc54vvgn154