Cargando…
Increased Incidence of Endoscopic Erosive Esophagitis in Solid Organ Transplant Recipients
BACKGROUND/AIMS: Solid organ transplant recipients frequently report gastrointestinal symptoms, especially heartburn or dyspepsia. However, the prevalence of endoscopic erosive esophagitis (EE) and associated risk factors after transplantation are unknown. The aim of this study was to determine whet...
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Korean Society of Gastroenterology; the Korean Society of Gastrointestinal Endoscopy; the Korean Association for the Study of the Liver; the Korean Society of Neurogastroenterology and Motility; Korean Association for the Study of Intestinal Diseases; Korean College of Helicobacter and Upper Gastrointestinal Research; Korean Pancreatobiliary Association; Korean Society of Gastrointestinal Cancer
2012
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3404173/ https://www.ncbi.nlm.nih.gov/pubmed/22844564 http://dx.doi.org/10.5009/gnl.2012.6.3.349 |
_version_ | 1782238996979515392 |
---|---|
author | Kim, In Soo Lee, Hyuk Park, Jun Chul Shin, Sung Kwan Lee, Sang Kil Lee, Yong Chan |
author_facet | Kim, In Soo Lee, Hyuk Park, Jun Chul Shin, Sung Kwan Lee, Sang Kil Lee, Yong Chan |
author_sort | Kim, In Soo |
collection | PubMed |
description | BACKGROUND/AIMS: Solid organ transplant recipients frequently report gastrointestinal symptoms, especially heartburn or dyspepsia. However, the prevalence of endoscopic erosive esophagitis (EE) and associated risk factors after transplantation are unknown. The aim of this study was to determine whether there was a high incidence of endoscopic findings of EE in solid organ transplant recipients. METHODS: This retrospective case-control study included 256 of 3,152 solid organ transplant recipients who underwent sequential screening upper endoscopic examinations and an equal number of controls. RESULTS: Forty-four (17.2%) and 16 (6.2%) cases of EE were detected in the solid organ transplant and control groups, respectively (p<0.001). In the multivariate analysis, transplantation was significantly associated with EE (odds ratio [OR], 6.48; 95% confidence interval, 2.74 to 15.35). Factors such as old age (OR, 1.17), the presence of a hiatal hernia (OR, 5.84), an increased duration of immunosuppression (OR, 1.07), and the maintenance administration of mycophenolate mofetil (OR, 4.13) were independently associated with the occurrence of EE in the solid organ transplant recipients. CONCLUSIONS: A significant increase in the incidence of endoscopically detected EE was observed in solid organ transplant recipients. This increased incidence was associated with the type and duration of the immunosuppressive therapy. |
format | Online Article Text |
id | pubmed-3404173 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | The Korean Society of Gastroenterology; the Korean Society of Gastrointestinal Endoscopy; the Korean Association for the Study of the Liver; the Korean Society of Neurogastroenterology and Motility; Korean Association for the Study of Intestinal Diseases; Korean College of Helicobacter and Upper Gastrointestinal Research; Korean Pancreatobiliary Association; Korean Society of Gastrointestinal Cancer |
record_format | MEDLINE/PubMed |
spelling | pubmed-34041732012-07-27 Increased Incidence of Endoscopic Erosive Esophagitis in Solid Organ Transplant Recipients Kim, In Soo Lee, Hyuk Park, Jun Chul Shin, Sung Kwan Lee, Sang Kil Lee, Yong Chan Gut Liver Original Article BACKGROUND/AIMS: Solid organ transplant recipients frequently report gastrointestinal symptoms, especially heartburn or dyspepsia. However, the prevalence of endoscopic erosive esophagitis (EE) and associated risk factors after transplantation are unknown. The aim of this study was to determine whether there was a high incidence of endoscopic findings of EE in solid organ transplant recipients. METHODS: This retrospective case-control study included 256 of 3,152 solid organ transplant recipients who underwent sequential screening upper endoscopic examinations and an equal number of controls. RESULTS: Forty-four (17.2%) and 16 (6.2%) cases of EE were detected in the solid organ transplant and control groups, respectively (p<0.001). In the multivariate analysis, transplantation was significantly associated with EE (odds ratio [OR], 6.48; 95% confidence interval, 2.74 to 15.35). Factors such as old age (OR, 1.17), the presence of a hiatal hernia (OR, 5.84), an increased duration of immunosuppression (OR, 1.07), and the maintenance administration of mycophenolate mofetil (OR, 4.13) were independently associated with the occurrence of EE in the solid organ transplant recipients. CONCLUSIONS: A significant increase in the incidence of endoscopically detected EE was observed in solid organ transplant recipients. This increased incidence was associated with the type and duration of the immunosuppressive therapy. The Korean Society of Gastroenterology; the Korean Society of Gastrointestinal Endoscopy; the Korean Association for the Study of the Liver; the Korean Society of Neurogastroenterology and Motility; Korean Association for the Study of Intestinal Diseases; Korean College of Helicobacter and Upper Gastrointestinal Research; Korean Pancreatobiliary Association; Korean Society of Gastrointestinal Cancer 2012-07 2012-07-12 /pmc/articles/PMC3404173/ /pubmed/22844564 http://dx.doi.org/10.5009/gnl.2012.6.3.349 Text en Copyright © 2012 by the Korean Society of Gastroenterology, the Korean Society of Gastrointestinal Endoscopy, the Korean Society of Neurogastroenterology and Motility, Korean College of Helicobacter and Upper Gastrointestinal Research, Korean Association for the Study of Intestinal Diseases, the Korean Association for the Study of the Liver, Korean Pancreatobiliary Association, and Korean Society of Gastrointestinal Cancer http://creativecommons.org/licenses/by-nc/3.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Kim, In Soo Lee, Hyuk Park, Jun Chul Shin, Sung Kwan Lee, Sang Kil Lee, Yong Chan Increased Incidence of Endoscopic Erosive Esophagitis in Solid Organ Transplant Recipients |
title | Increased Incidence of Endoscopic Erosive Esophagitis in Solid Organ Transplant Recipients |
title_full | Increased Incidence of Endoscopic Erosive Esophagitis in Solid Organ Transplant Recipients |
title_fullStr | Increased Incidence of Endoscopic Erosive Esophagitis in Solid Organ Transplant Recipients |
title_full_unstemmed | Increased Incidence of Endoscopic Erosive Esophagitis in Solid Organ Transplant Recipients |
title_short | Increased Incidence of Endoscopic Erosive Esophagitis in Solid Organ Transplant Recipients |
title_sort | increased incidence of endoscopic erosive esophagitis in solid organ transplant recipients |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3404173/ https://www.ncbi.nlm.nih.gov/pubmed/22844564 http://dx.doi.org/10.5009/gnl.2012.6.3.349 |
work_keys_str_mv | AT kiminsoo increasedincidenceofendoscopicerosiveesophagitisinsolidorgantransplantrecipients AT leehyuk increasedincidenceofendoscopicerosiveesophagitisinsolidorgantransplantrecipients AT parkjunchul increasedincidenceofendoscopicerosiveesophagitisinsolidorgantransplantrecipients AT shinsungkwan increasedincidenceofendoscopicerosiveesophagitisinsolidorgantransplantrecipients AT leesangkil increasedincidenceofendoscopicerosiveesophagitisinsolidorgantransplantrecipients AT leeyongchan increasedincidenceofendoscopicerosiveesophagitisinsolidorgantransplantrecipients |