Cargando…
Effect of Nonalcoholic Fatty Liver Disease on the Development of Type 2 Diabetes in Nonobese, Nondiabetic Korean Men
BACKGROUND/AIMS: We have a limited understanding of the effect of nonalcoholic fatty liver disease (NAFLD) on the development of type 2 diabetes. METHODS: The study subjects included male who had received biennial medical check-ups between 2005 and 2009 and who had been diagnosed with fatty liver di...
Autores principales: | , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Korean Society of Gastroenterology; the Korean Society of Gastrointestinal Endoscopy; the Korean Association for the Study of the Liver; the Korean Society of Neurogastroenterology and Motility; Korean Association for the Study of Intestinal Diseases; Korean College of Helicobacter and Upper Gastrointestinal Research; Korean Pancreatobiliary Association; Korean Society of Gastrointestinal Cancer
2012
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3404176/ https://www.ncbi.nlm.nih.gov/pubmed/22844567 http://dx.doi.org/10.5009/gnl.2012.6.3.368 |
_version_ | 1782238997691498496 |
---|---|
author | Chon, Chang Wook Kim, Bum Soo Cho, Yong Kyun Sung, Ki Chul Bae, Ji Cheol Kim, Tae Wan Won, Hyun Sun Joo, Kwan Joong |
author_facet | Chon, Chang Wook Kim, Bum Soo Cho, Yong Kyun Sung, Ki Chul Bae, Ji Cheol Kim, Tae Wan Won, Hyun Sun Joo, Kwan Joong |
author_sort | Chon, Chang Wook |
collection | PubMed |
description | BACKGROUND/AIMS: We have a limited understanding of the effect of nonalcoholic fatty liver disease (NAFLD) on the development of type 2 diabetes. METHODS: The study subjects included male who had received biennial medical check-ups between 2005 and 2009 and who had been diagnosed with fatty liver disease. The subjects with sustained NAFLD (FL, n=107) and sustained non-NAFLD (NFL, n=1,054) were followed to determine the development of type 2 diabetes. RESULTS: In the FL group, there were more subjects with impaired fasting glucose (IFG), type 2 diabetes and high HOMA-IR than there were in the NFL group during the 5-year follow-up period (32.7 vs. 17.6%, 1.9 vs. 0.3%, 17.9 vs. 5.2% respectively, p<0.05). The FL group showed a higher risk than NFL group for abnormal glucose metabolism as determined using IFG (odds ratio [OR], 2.13; confidence interval [CI], 1.36 to 3.35), type 2 diabetes (OR, 7.63; 95% CI, 1.03 to 56.79) and high HOMA-IR (OR, 3.25; 95% CI, 1.79 to 5.91) and metabolic parameters such as body mass index (OR, 3.35; 95% CI, 1.87 to 6.02), triglyceride (OR, 3.05; 95% CI, 1.92 to 4.86) and fasting blood sugar (OR, 2.18; 95% CI, 1.39 to 3.41). CONCLUSIONS: Sustained NAFLD appears to be associated with an increased risk for the development of type 2 diabetes and deterioration of metabolic parameters in non-obese, non-diabetic Korean men. |
format | Online Article Text |
id | pubmed-3404176 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | The Korean Society of Gastroenterology; the Korean Society of Gastrointestinal Endoscopy; the Korean Association for the Study of the Liver; the Korean Society of Neurogastroenterology and Motility; Korean Association for the Study of Intestinal Diseases; Korean College of Helicobacter and Upper Gastrointestinal Research; Korean Pancreatobiliary Association; Korean Society of Gastrointestinal Cancer |
record_format | MEDLINE/PubMed |
spelling | pubmed-34041762012-07-27 Effect of Nonalcoholic Fatty Liver Disease on the Development of Type 2 Diabetes in Nonobese, Nondiabetic Korean Men Chon, Chang Wook Kim, Bum Soo Cho, Yong Kyun Sung, Ki Chul Bae, Ji Cheol Kim, Tae Wan Won, Hyun Sun Joo, Kwan Joong Gut Liver Original Article BACKGROUND/AIMS: We have a limited understanding of the effect of nonalcoholic fatty liver disease (NAFLD) on the development of type 2 diabetes. METHODS: The study subjects included male who had received biennial medical check-ups between 2005 and 2009 and who had been diagnosed with fatty liver disease. The subjects with sustained NAFLD (FL, n=107) and sustained non-NAFLD (NFL, n=1,054) were followed to determine the development of type 2 diabetes. RESULTS: In the FL group, there were more subjects with impaired fasting glucose (IFG), type 2 diabetes and high HOMA-IR than there were in the NFL group during the 5-year follow-up period (32.7 vs. 17.6%, 1.9 vs. 0.3%, 17.9 vs. 5.2% respectively, p<0.05). The FL group showed a higher risk than NFL group for abnormal glucose metabolism as determined using IFG (odds ratio [OR], 2.13; confidence interval [CI], 1.36 to 3.35), type 2 diabetes (OR, 7.63; 95% CI, 1.03 to 56.79) and high HOMA-IR (OR, 3.25; 95% CI, 1.79 to 5.91) and metabolic parameters such as body mass index (OR, 3.35; 95% CI, 1.87 to 6.02), triglyceride (OR, 3.05; 95% CI, 1.92 to 4.86) and fasting blood sugar (OR, 2.18; 95% CI, 1.39 to 3.41). CONCLUSIONS: Sustained NAFLD appears to be associated with an increased risk for the development of type 2 diabetes and deterioration of metabolic parameters in non-obese, non-diabetic Korean men. The Korean Society of Gastroenterology; the Korean Society of Gastrointestinal Endoscopy; the Korean Association for the Study of the Liver; the Korean Society of Neurogastroenterology and Motility; Korean Association for the Study of Intestinal Diseases; Korean College of Helicobacter and Upper Gastrointestinal Research; Korean Pancreatobiliary Association; Korean Society of Gastrointestinal Cancer 2012-07 2012-07-12 /pmc/articles/PMC3404176/ /pubmed/22844567 http://dx.doi.org/10.5009/gnl.2012.6.3.368 Text en Copyright © 2012 by the Korean Society of Gastroenterology, the Korean Society of Gastrointestinal Endoscopy, the Korean Society of Neurogastroenterology and Motility, Korean College of Helicobacter and Upper Gastrointestinal Research, Korean Association for the Study of Intestinal Diseases, the Korean Association for the Study of the Liver, Korean Pancreatobiliary Association, and Korean Society of Gastrointestinal Cancer http://creativecommons.org/licenses/by-nc/3.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Chon, Chang Wook Kim, Bum Soo Cho, Yong Kyun Sung, Ki Chul Bae, Ji Cheol Kim, Tae Wan Won, Hyun Sun Joo, Kwan Joong Effect of Nonalcoholic Fatty Liver Disease on the Development of Type 2 Diabetes in Nonobese, Nondiabetic Korean Men |
title | Effect of Nonalcoholic Fatty Liver Disease on the Development of Type 2 Diabetes in Nonobese, Nondiabetic Korean Men |
title_full | Effect of Nonalcoholic Fatty Liver Disease on the Development of Type 2 Diabetes in Nonobese, Nondiabetic Korean Men |
title_fullStr | Effect of Nonalcoholic Fatty Liver Disease on the Development of Type 2 Diabetes in Nonobese, Nondiabetic Korean Men |
title_full_unstemmed | Effect of Nonalcoholic Fatty Liver Disease on the Development of Type 2 Diabetes in Nonobese, Nondiabetic Korean Men |
title_short | Effect of Nonalcoholic Fatty Liver Disease on the Development of Type 2 Diabetes in Nonobese, Nondiabetic Korean Men |
title_sort | effect of nonalcoholic fatty liver disease on the development of type 2 diabetes in nonobese, nondiabetic korean men |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3404176/ https://www.ncbi.nlm.nih.gov/pubmed/22844567 http://dx.doi.org/10.5009/gnl.2012.6.3.368 |
work_keys_str_mv | AT chonchangwook effectofnonalcoholicfattyliverdiseaseonthedevelopmentoftype2diabetesinnonobesenondiabetickoreanmen AT kimbumsoo effectofnonalcoholicfattyliverdiseaseonthedevelopmentoftype2diabetesinnonobesenondiabetickoreanmen AT choyongkyun effectofnonalcoholicfattyliverdiseaseonthedevelopmentoftype2diabetesinnonobesenondiabetickoreanmen AT sungkichul effectofnonalcoholicfattyliverdiseaseonthedevelopmentoftype2diabetesinnonobesenondiabetickoreanmen AT baejicheol effectofnonalcoholicfattyliverdiseaseonthedevelopmentoftype2diabetesinnonobesenondiabetickoreanmen AT kimtaewan effectofnonalcoholicfattyliverdiseaseonthedevelopmentoftype2diabetesinnonobesenondiabetickoreanmen AT wonhyunsun effectofnonalcoholicfattyliverdiseaseonthedevelopmentoftype2diabetesinnonobesenondiabetickoreanmen AT jookwanjoong effectofnonalcoholicfattyliverdiseaseonthedevelopmentoftype2diabetesinnonobesenondiabetickoreanmen |