Increased Risk of Noninfluenza Respiratory Virus Infections Associated With Receipt of Inactivated Influenza Vaccine

We randomized 115 children to trivalent inactivated influenza vaccine (TIV) or placebo. Over the following 9 months, TIV recipients had an increased risk of virologically-confirmed non-influenza infections (relative risk: 4.40; 95% confidence interval: 1.31-14.8). Being protected against influenza,...

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Detalles Bibliográficos
Autores principales: Cowling, Benjamin J., Fang, Vicky J., Nishiura, Hiroshi, Chan, Kwok-Hung, Ng, Sophia, Ip, Dennis K. M., Chiu, Susan S., Leung, Gabriel M., Peiris, J. S. Malik
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2012
Materias:
Brief Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3404712/
https://www.ncbi.nlm.nih.gov/pubmed/22423139
http://dx.doi.org/10.1093/cid/cis307
Descripción
Sumario:We randomized 115 children to trivalent inactivated influenza vaccine (TIV) or placebo. Over the following 9 months, TIV recipients had an increased risk of virologically-confirmed non-influenza infections (relative risk: 4.40; 95% confidence interval: 1.31-14.8). Being protected against influenza, TIV recipients may lack temporary non-specific immunity that protected against other respiratory viruses.

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