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Pyridoxal 5′-Phosphate Is a Slow Tight Binding Inhibitor of E. coli Pyridoxal Kinase

Pyridoxal 5′-phosphate (PLP) is a cofactor for dozens of B(6) requiring enzymes. PLP reacts with apo-B(6) enzymes by forming an aldimine linkage with the ε-amino group of an active site lysine residue, thus yielding the catalytically active holo-B(6) enzyme. During protein turnover, the PLP is salva...

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Detalles Bibliográficos
Autores principales:	Ghatge, Mohini S., Contestabile, Roberto, di Salvo, Martino L., Desai, Jigar V., Gandhi, Amit K., Camara, Christina M., Florio, Rita, González, Isabel N., Parroni, Alessia, Schirch, Verne, Safo, Martin K.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3404986/ https://www.ncbi.nlm.nih.gov/pubmed/22848564 http://dx.doi.org/10.1371/journal.pone.0041680

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