Haploinsufficiency for Translation Elongation Factor eEF1A2 in Aged Mouse Muscle and Neurons Is Compatible with Normal Function

Translation elongation factor isoform eEF1A2 is expressed in muscle and neurons. Deletion of eEF1A2 in mice gives rise to the neurodegenerative phenotype “wasted” (wst). Mice homozygous for the wasted mutation die of muscle wasting and neurodegeneration at four weeks post-natal. Although the mutatio...

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Detalles Bibliográficos
Autores principales: Griffiths, Lowri A., Doig, Jennifer, Churchhouse, Antonia M. D., Davies, Faith C. J., Squires, Charlotte E., Newbery, Helen J., Abbott, Catherine M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3405021/
https://www.ncbi.nlm.nih.gov/pubmed/22848658
http://dx.doi.org/10.1371/journal.pone.0041917

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