Cargando…

Inhibition of Sphingosine Kinase-2 Suppresses Inflammation and Attenuates Graft Injury after Liver Transplantation in Rats

Inflammation mediates/promotes graft injury after liver transplantation (LT). This study investigated the roles of sphingosine kinase-2 (SK2) in inflammation after LT. Liver grafts were stored in UW solution with and without ABC294640 (100 µM), a selective inhibitor of SK2, before implantation. Hepa...

Descripción completa

Detalles Bibliográficos
Autores principales:	Liu, Qinlong, Rehman, Hasibur, Shi, Yanjun, Krishnasamy, Yasodha, Lemasters, John J., Smith, Charles D., Zhong, Zhi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3405047/ https://www.ncbi.nlm.nih.gov/pubmed/22848628 http://dx.doi.org/10.1371/journal.pone.0041834

Ejemplares similares

Disrupted Renal Mitochondrial Homeostasis after Liver Transplantation in Rats
por: Liu, Qinlong, et al.
Publicado: (2015)

Acute Ethanol Causes Hepatic Mitochondrial Depolarization in Mice: Role of Ethanol Metabolism
por: Zhong, Zhi, et al.
Publicado: (2014)

Small-for-Size Liver Transplantation Increases Pulmonary Injury in Rats: Prevention by NIM811
por: Liu, Qinlong, et al.
Publicado: (2012)

Green Tea Polyphenols Stimulate Mitochondrial Biogenesis and Improve Renal Function after Chronic Cyclosporin A Treatment in Rats
por: Rehman, Hasibur, et al.
Publicado: (2013)

Ethanol and High Cholesterol Diet Causes Severe Steatohepatitis and Early Liver Fibrosis in Mice
por: Krishnasamy, Yasodha, et al.
Publicado: (2016)

LP342, a novel histone deacetylase inhibitor, decreases nitro-oxidative stress, mitochondrial dysfunction and hepatic ischaemia/reperfusion injury in mice
por: Samuvel, Devadoss J, et al.
Publicado: (2023)

The sphingosine kinase inhibitor SKI-V suppresses cervical cancer cell growth
por: Zhang, Yan, et al.
Publicado: (2022)

Drugging Sphingosine Kinases
por: Santos, Webster L., et al.
Publicado: (2014)

Suppression of Graft Regeneration, Not Ischemia/Reperfusion Injury, Is the Primary Cause of Small-for-Size Syndrome after Partial Liver Transplantation in Mice
por: Pan, Ning, et al.
Publicado: (2014)

A Novel Sphingosine Kinase Inhibitor Suppresses Chikungunya Virus Infection
por: Oyewole, Opeoluwa O., et al.
Publicado: (2022)

Sphingosine Kinase 1 and Sphingosine-1-Phosphate Signaling in Colorectal Cancer
por: Bao, Yonghua, et al.
Publicado: (2017)

Interaction of microRNAs with sphingosine kinases, sphingosine-1 phosphate, and sphingosine-1 phosphate receptors in cancer
por: Xu, Guangmeng, et al.
Publicado: (2021)

TRAF2 regulates TNF and NF-κB signalling to suppress apoptosis and skin inflammation independently of Sphingosine kinase 1
por: Etemadi, Nima, et al.
Publicado: (2015)

Deletion of sphingosine kinase 2 attenuates cigarette smoke-mediated chronic obstructive pulmonary disease-like symptoms by reducing lung inflammation
por: Chen, Yanhui, et al.
Publicado: (2023)

Sphingosine Kinases/Sphingosine-1-Phosphate and Death Signalling in APP-Transfected Cells
por: Gassowska, Magdalena, et al.
Publicado: (2014)

Characterizing Sphingosine Kinases and Sphingosine 1-Phosphate Receptors in the Mammalian Eye and Retina
por: Porter, Hunter, et al.
Publicado: (2018)

Sphingosine Kinases and Sphingosine 1-Phosphate Receptors: Signaling and Actions in the Cardiovascular System
por: Cannavo, Alessandro, et al.
Publicado: (2017)

The role of the sphingosine axis in immune regulation: A dichotomy in the anti-inflammatory effects between sphingosine kinase 1 and sphingosine kinase 2-dependent pathways
por: Ishay, Yuval, et al.
Publicado: (2021)

Characterization of Isoenzyme-Selective Inhibitors of Human Sphingosine Kinases
por: Gao, Peng, et al.
Publicado: (2012)

Reduced sphingosine kinase-1 and enhanced sphingosine 1-phosphate lyase expression demonstrate deregulated sphingosine 1-phosphate signaling in Alzheimer’s disease
por: Ceccom, Johnatan, et al.
Publicado: (2014)

An oncogenic role for sphingosine kinase 2
por: Neubauer, Heidi A., et al.
Publicado: (2016)

Sphingosine kinase 2 and multiple myeloma
por: Pyne, Nigel J., et al.
Publicado: (2017)

Transcriptional Regulation of Sphingosine Kinase 1
por: Bonica, Joseph, et al.
Publicado: (2020)

The Functional Role of Sphingosine Kinase 2
por: Diaz Escarcega, Rocio, et al.
Publicado: (2021)

Role of sphingosine kinase and sphingosine-1-phosphate receptor in the liver pathology of mice infected with Plasmodium berghei ANKA
por: Techarang, Tachpon, et al.
Publicado: (2022)

The sphingosine kinase 1 activator, K6PC-5, attenuates Ebola virus infection
por: Imre, Gergely, et al.
Publicado: (2021)

The Impact of Sphingosine Kinases on Inflammation-Induced Cytokine Release and Vascular Endothelial Barrier Integrity
por: Thuy, Andreas V., et al.
Publicado: (2022)

Correction: TRAF2 regulates TNF and NF-κB signalling to suppress apoptosis and skin inflammation independently of Sphingosine kinase 1
por: Etemadi, Nima, et al.
Publicado: (2017)

Commentary: The sphingosine kinase 1/sphingosine-1-phosphate pathway in pulmonary arterial hypertension
por: Bhavanam, Naga P., et al.
Publicado: (2015)

Impairment of Angiogenic Sphingosine Kinase-1/Sphingosine-1-Phosphate Receptors Pathway in Preeclampsia
por: Dobierzewska, Aneta, et al.
Publicado: (2016)

Macrophage Sphingosine 1-Phosphate Receptor 2 Blockade Attenuates Liver Inflammation and Fibrogenesis Triggered by NLRP3 Inflammasome
por: Hou, Lei, et al.
Publicado: (2020)

Sphingosine Kinase 1 and Cancer: A Systematic Review and Meta-Analysis
por: Zhang, Yun, et al.
Publicado: (2014)

Suppression of c-Myc and RRM2 expression in pancreatic cancer cells by the sphingosine kinase-2 inhibitor ABC294640
por: Lewis, Clayton S., et al.
Publicado: (2016)

Peretinoin, an acyclic retinoid, inhibits hepatocarcinogenesis by suppressing sphingosine kinase 1 expression in vitro and in vivo
por: Funaki, Masaya, et al.
Publicado: (2017)

Ablation of sphingosine kinase 2 suppresses fatty liver-associated hepatocellular carcinoma via downregulation of ceramide transfer protein
por: Liu, Xin Tracy, et al.
Publicado: (2022)

Dengue Virus-Induced Inflammation of the Endothelium and the Potential Roles of Sphingosine Kinase-1 and MicroRNAs
por: Aloia, Amanda L., et al.
Publicado: (2015)

Regulation of cellular sphingosine-1-phosphate by sphingosine kinase 1 and sphingosine-1-phopshate lyase determines chemotherapy resistance in gastroesophageal cancer
por: Matula, Kasia, et al.
Publicado: (2015)

Sphingosine Kinase Expression Increases Intracellular Sphingosine-1-Phosphate and Promotes Cell Growth and Survival
por: Olivera, Ana, et al.
Publicado: (1999)

Regulatory role of sphingosine kinase and sphingosine-1-phosphate receptor signaling in progenitor/stem cells
por: Ng, Mei Li, et al.
Publicado: (2018)

Targeting the Sphingosine Kinase/Sphingosine-1-Phosphate Signaling Axis in Drug Discovery for Cancer Therapy
por: Gupta, Preeti, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_p24pmte61bvl90eirb3rdko7ua