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Weight Cycling Enhances Adipose Tissue Inflammatory Responses in Male Mice

BACKGROUND: Obesity is associated with low-grade chronic inflammation attributed to dysregulated production, release of cytokines and adipokines and to dysregulated glucose-insulin homeostasis and dyslipidemia. Nutritional interventions such as dieting are often accompanied by repeated bouts of weig...

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Autores principales: Barbosa-da-Silva, Sandra, Fraulob-Aquino, Julio C., Lopes, Jessica R., Mandarim-de-Lacerda, Carlos A., Aguila, Marcia B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3405086/
https://www.ncbi.nlm.nih.gov/pubmed/22848362
http://dx.doi.org/10.1371/journal.pone.0039837
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author Barbosa-da-Silva, Sandra
Fraulob-Aquino, Julio C.
Lopes, Jessica R.
Mandarim-de-Lacerda, Carlos A.
Aguila, Marcia B.
author_facet Barbosa-da-Silva, Sandra
Fraulob-Aquino, Julio C.
Lopes, Jessica R.
Mandarim-de-Lacerda, Carlos A.
Aguila, Marcia B.
author_sort Barbosa-da-Silva, Sandra
collection PubMed
description BACKGROUND: Obesity is associated with low-grade chronic inflammation attributed to dysregulated production, release of cytokines and adipokines and to dysregulated glucose-insulin homeostasis and dyslipidemia. Nutritional interventions such as dieting are often accompanied by repeated bouts of weight loss and regain, a phenomenon known as weight cycling (WC). METHODS: In this work we studied the effects of WC on the feed efficiency, blood lipids, carbohydrate metabolism, adiposity and inflammatory markers in C57BL/6 male mice that WC two or three consecutive times by alternation of a high-fat (HF) diet with standard chow (SC). RESULTS: The body mass (BM) grew up in each cycle of HF feeding, and decreased after each cycle of SC feeding. The alterations observed in the animals feeding HF diet in the oral glucose tolerance test, in blood lipids, and in serum and adipose tissue expression of adipokines were not recuperated after WC. Moreover, the longer the HF feeding was (two, four and six months), more severe the adiposity was. After three consecutive WC, less marked was the BM reduction during SC feeding, while more severe was the BM increase during HF feeding. CONCLUSION: In conclusion, the results of the present study showed that both the HF diet and WC are relevant to BM evolution and fat pad remodeling in mice, with repercussion in blood lipids, homeostasis of glucose-insulin and adipokine levels. The simple reduction of the BM during a WC is not able to recover the high levels of adipokines in the serum and adipose tissue as well as the pro-inflammatory cytokines enhanced during a cycle of HF diet. These findings are significant because a milieu with altered adipokines in association with WC potentially aggravates the chronic inflammation attributed to dysregulated production and release of adipokines in mice.
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spelling pubmed-34050862012-07-30 Weight Cycling Enhances Adipose Tissue Inflammatory Responses in Male Mice Barbosa-da-Silva, Sandra Fraulob-Aquino, Julio C. Lopes, Jessica R. Mandarim-de-Lacerda, Carlos A. Aguila, Marcia B. PLoS One Research Article BACKGROUND: Obesity is associated with low-grade chronic inflammation attributed to dysregulated production, release of cytokines and adipokines and to dysregulated glucose-insulin homeostasis and dyslipidemia. Nutritional interventions such as dieting are often accompanied by repeated bouts of weight loss and regain, a phenomenon known as weight cycling (WC). METHODS: In this work we studied the effects of WC on the feed efficiency, blood lipids, carbohydrate metabolism, adiposity and inflammatory markers in C57BL/6 male mice that WC two or three consecutive times by alternation of a high-fat (HF) diet with standard chow (SC). RESULTS: The body mass (BM) grew up in each cycle of HF feeding, and decreased after each cycle of SC feeding. The alterations observed in the animals feeding HF diet in the oral glucose tolerance test, in blood lipids, and in serum and adipose tissue expression of adipokines were not recuperated after WC. Moreover, the longer the HF feeding was (two, four and six months), more severe the adiposity was. After three consecutive WC, less marked was the BM reduction during SC feeding, while more severe was the BM increase during HF feeding. CONCLUSION: In conclusion, the results of the present study showed that both the HF diet and WC are relevant to BM evolution and fat pad remodeling in mice, with repercussion in blood lipids, homeostasis of glucose-insulin and adipokine levels. The simple reduction of the BM during a WC is not able to recover the high levels of adipokines in the serum and adipose tissue as well as the pro-inflammatory cytokines enhanced during a cycle of HF diet. These findings are significant because a milieu with altered adipokines in association with WC potentially aggravates the chronic inflammation attributed to dysregulated production and release of adipokines in mice. Public Library of Science 2012-07-25 /pmc/articles/PMC3405086/ /pubmed/22848362 http://dx.doi.org/10.1371/journal.pone.0039837 Text en Barbosa-da-Silva et al. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Barbosa-da-Silva, Sandra
Fraulob-Aquino, Julio C.
Lopes, Jessica R.
Mandarim-de-Lacerda, Carlos A.
Aguila, Marcia B.
Weight Cycling Enhances Adipose Tissue Inflammatory Responses in Male Mice
title Weight Cycling Enhances Adipose Tissue Inflammatory Responses in Male Mice
title_full Weight Cycling Enhances Adipose Tissue Inflammatory Responses in Male Mice
title_fullStr Weight Cycling Enhances Adipose Tissue Inflammatory Responses in Male Mice
title_full_unstemmed Weight Cycling Enhances Adipose Tissue Inflammatory Responses in Male Mice
title_short Weight Cycling Enhances Adipose Tissue Inflammatory Responses in Male Mice
title_sort weight cycling enhances adipose tissue inflammatory responses in male mice
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3405086/
https://www.ncbi.nlm.nih.gov/pubmed/22848362
http://dx.doi.org/10.1371/journal.pone.0039837
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