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Heritability Estimates of Body Size in Fetal Life and Early Childhood
BACKGROUND: The objective was to estimate the heritability for height and weight during fetal life and early childhood in two independent studies, one including parent and singleton offsprings and one of mono- and dizygotic twins. METHODS: This study was embedded in the Generation R Study (n = 3407,...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3405108/ https://www.ncbi.nlm.nih.gov/pubmed/22848364 http://dx.doi.org/10.1371/journal.pone.0039901 |
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author | Mook-Kanamori, Dennis O. van Beijsterveldt, Catharina E. M. Steegers, Eric A. P. Aulchenko, Yurii S. Raat, Hein Hofman, Albert Eilers, Paul H. Boomsma, Dorret I. Jaddoe, Vincent W. V. |
author_facet | Mook-Kanamori, Dennis O. van Beijsterveldt, Catharina E. M. Steegers, Eric A. P. Aulchenko, Yurii S. Raat, Hein Hofman, Albert Eilers, Paul H. Boomsma, Dorret I. Jaddoe, Vincent W. V. |
author_sort | Mook-Kanamori, Dennis O. |
collection | PubMed |
description | BACKGROUND: The objective was to estimate the heritability for height and weight during fetal life and early childhood in two independent studies, one including parent and singleton offsprings and one of mono- and dizygotic twins. METHODS: This study was embedded in the Generation R Study (n = 3407, singletons) and the Netherlands Twin Register (n = 33694, twins). For the heritability estimates in Generation R, regression models as proposed by Galton were used. In the Twin Register we used genetic structural equation modelling. Parental height and weight were measured and fetal growth characteristics (femur length and estimated fetal weight) were measured by ultrasounds in 2(nd) and 3(rd) trimester (Generation R only). Height and weight were assessed at multiple time-points from birth to 36 months in both studies. RESULTS: Heritability estimates for length increased from 2(nd) to 3(rd) trimester from 13% to 28%. At birth, heritability estimates for length in singletons and twins were both 26% and 27%, respectively, and at 36 months, the estimates for height were 63% and 72%, respectively. Heritability estimates for fetal weight increased from 2(nd) to 3(rd) trimester from 17% to 27%. For birth weight, heritability estimates were 26% in singletons and 29% in twins. At 36 months, the estimate for twins was 71% and higher than for singletons (42%). CONCLUSIONS: Heritability estimates for height and weight increase from second trimester to infancy. This increase in heritability is observed in singletons and twins. Longer follow-up studies are needed to examine how the heritability develops in later childhood and puberty. |
format | Online Article Text |
id | pubmed-3405108 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-34051082012-07-30 Heritability Estimates of Body Size in Fetal Life and Early Childhood Mook-Kanamori, Dennis O. van Beijsterveldt, Catharina E. M. Steegers, Eric A. P. Aulchenko, Yurii S. Raat, Hein Hofman, Albert Eilers, Paul H. Boomsma, Dorret I. Jaddoe, Vincent W. V. PLoS One Research Article BACKGROUND: The objective was to estimate the heritability for height and weight during fetal life and early childhood in two independent studies, one including parent and singleton offsprings and one of mono- and dizygotic twins. METHODS: This study was embedded in the Generation R Study (n = 3407, singletons) and the Netherlands Twin Register (n = 33694, twins). For the heritability estimates in Generation R, regression models as proposed by Galton were used. In the Twin Register we used genetic structural equation modelling. Parental height and weight were measured and fetal growth characteristics (femur length and estimated fetal weight) were measured by ultrasounds in 2(nd) and 3(rd) trimester (Generation R only). Height and weight were assessed at multiple time-points from birth to 36 months in both studies. RESULTS: Heritability estimates for length increased from 2(nd) to 3(rd) trimester from 13% to 28%. At birth, heritability estimates for length in singletons and twins were both 26% and 27%, respectively, and at 36 months, the estimates for height were 63% and 72%, respectively. Heritability estimates for fetal weight increased from 2(nd) to 3(rd) trimester from 17% to 27%. For birth weight, heritability estimates were 26% in singletons and 29% in twins. At 36 months, the estimate for twins was 71% and higher than for singletons (42%). CONCLUSIONS: Heritability estimates for height and weight increase from second trimester to infancy. This increase in heritability is observed in singletons and twins. Longer follow-up studies are needed to examine how the heritability develops in later childhood and puberty. Public Library of Science 2012-07-25 /pmc/articles/PMC3405108/ /pubmed/22848364 http://dx.doi.org/10.1371/journal.pone.0039901 Text en Mook-Kanamori et al. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article Mook-Kanamori, Dennis O. van Beijsterveldt, Catharina E. M. Steegers, Eric A. P. Aulchenko, Yurii S. Raat, Hein Hofman, Albert Eilers, Paul H. Boomsma, Dorret I. Jaddoe, Vincent W. V. Heritability Estimates of Body Size in Fetal Life and Early Childhood |
title | Heritability Estimates of Body Size in Fetal Life and Early Childhood |
title_full | Heritability Estimates of Body Size in Fetal Life and Early Childhood |
title_fullStr | Heritability Estimates of Body Size in Fetal Life and Early Childhood |
title_full_unstemmed | Heritability Estimates of Body Size in Fetal Life and Early Childhood |
title_short | Heritability Estimates of Body Size in Fetal Life and Early Childhood |
title_sort | heritability estimates of body size in fetal life and early childhood |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3405108/ https://www.ncbi.nlm.nih.gov/pubmed/22848364 http://dx.doi.org/10.1371/journal.pone.0039901 |
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