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Mapping the Mutual Information Network of Enzymatic Families in the Protein Structure to Unveil Functional Features
Amino acids committed to a particular function correlate tightly along evolution and tend to form clusters in the 3D structure of the protein. Consequently, a protein can be seen as a network of co-evolving clusters of residues. The goal of this work is two-fold: first, we have combined mutual infor...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2012
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3405127/ https://www.ncbi.nlm.nih.gov/pubmed/22848494 http://dx.doi.org/10.1371/journal.pone.0041430 |