That the effects of smoking should be measured in pack-years: misconceptions 4

Lung cancer incidence in smokers is roughly proportional to dose rate (cigarettes per day) but increases much more rapidly with duration of smoking. The assumption that the incidence rate is proportional to total lifetime dose (the product of dose rate and duration) has been known to be wrong for ma...

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Detalles Bibliográficos
Autor principal: Peto, J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2012
Materias:
Editorial
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3405232/
https://www.ncbi.nlm.nih.gov/pubmed/22828655
http://dx.doi.org/10.1038/bjc.2012.97
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description Lung cancer incidence in smokers is roughly proportional to dose rate (cigarettes per day) but increases much more rapidly with duration of smoking. The assumption that the incidence rate is proportional to total lifetime dose (the product of dose rate and duration) has been known to be wrong for many years, but total dose in pack-years is still often included, either alone or together, with more fundamental parameters such as dose rate, in regression analysis of epidemiological data. This is mathematically unnecessary and scientifically unhelpful.
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spelling pubmed-34052322013-07-24 That the effects of smoking should be measured in pack-years: misconceptions 4 Peto, J Br J Cancer Editorial Lung cancer incidence in smokers is roughly proportional to dose rate (cigarettes per day) but increases much more rapidly with duration of smoking. The assumption that the incidence rate is proportional to total lifetime dose (the product of dose rate and duration) has been known to be wrong for many years, but total dose in pack-years is still often included, either alone or together, with more fundamental parameters such as dose rate, in regression analysis of epidemiological data. This is mathematically unnecessary and scientifically unhelpful. Nature Publishing Group 2012-07-24 2012-07-24 /pmc/articles/PMC3405232/ /pubmed/22828655 http://dx.doi.org/10.1038/bjc.2012.97 Text en Copyright © 2012 Cancer Research UK https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Editorial
Peto, J
That the effects of smoking should be measured in pack-years: misconceptions 4
title That the effects of smoking should be measured in pack-years: misconceptions 4
title_full That the effects of smoking should be measured in pack-years: misconceptions 4
title_fullStr That the effects of smoking should be measured in pack-years: misconceptions 4
title_full_unstemmed That the effects of smoking should be measured in pack-years: misconceptions 4
title_short That the effects of smoking should be measured in pack-years: misconceptions 4
title_sort that the effects of smoking should be measured in pack-years: misconceptions 4
topic Editorial
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3405232/
https://www.ncbi.nlm.nih.gov/pubmed/22828655
http://dx.doi.org/10.1038/bjc.2012.97
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