Cargando…
Inhibition of impurities formation in the synthesis of N-alkyltheobromines stimulated by microwave irradiation. Cationic and anionic response of membrane electrodes
ABSTRACT: N-Alkyltheobromine (1–9) derivatives were obtained by reacting theobromine with appropriate alkyl halide under microwave irradiation at 100–150 W and by conventional synthesis. Formation of by-products of oxygen atom alkylation and 1-N-alkyltheobromine ring opening were considered. The pre...
Autores principales: | , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Netherlands
2011
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3405244/ https://www.ncbi.nlm.nih.gov/pubmed/22866022 http://dx.doi.org/10.1007/s10847-011-0093-5 |
Sumario: | ABSTRACT: N-Alkyltheobromine (1–9) derivatives were obtained by reacting theobromine with appropriate alkyl halide under microwave irradiation at 100–150 W and by conventional synthesis. Formation of by-products of oxygen atom alkylation and 1-N-alkyltheobromine ring opening were considered. The presented compounds 1–5 have been studied as ion carriers in ion-selective membrane electrodes. Selectivity of these membranes was studied towards various anions in addition to transition and heavy metal cations. GRAPHICAL ABSTRACT: Alkylations of theobromine under microwave irradiation at 100–150 W and by conventional synthesis were performed. Formation of by-products of oxygen atom alkylation and 1-N-alkyltheobromine ring opening were observed. The achieved compounds have been studied as ion carriers in ion-selective membrane electrodes. [Image: see text] |
---|