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Complexity of a complex trait locus: HP, HPR, haemoglobin and cholesterol

HP and HPR are related and contiguous genes in strong linkage disequilibrium (LD), encoding haptoglobin and haptoglobin-related protein. These bind and chaperone free Hb for recycling, protecting against oxidation. A copy number variation (CNV) within HP (Hp1/Hp2) results in different possible hapto...

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Detalles Bibliográficos
Autores principales:	Guthrie, Philip A.I., Rodriguez, Santiago, Gaunt, Tom R., Lawlor, Debbie A., Smith, George Davey, Day, Ian N.M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier/North-Holland 2012
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3405512/ https://www.ncbi.nlm.nih.gov/pubmed/22433445 http://dx.doi.org/10.1016/j.gene.2012.03.034

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