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HAM proteins promote organ indeterminacy: But how?
HAIRY MERISTEM (HAM) proteins, members of the GRAS family of transcriptional regulators, are essential for maintenance of indeterminate growth in flowering plant shoots, loss-of-function ham mutants exhibiting a strikingly novel phenotype of shoot meristem arrest and differentiation. Specific cellul...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Landes Bioscience
2012
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3405703/ https://www.ncbi.nlm.nih.gov/pubmed/22353859 http://dx.doi.org/10.4161/psb.18958 |
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author | Engstrom, Eric M. |
author_facet | Engstrom, Eric M. |
author_sort | Engstrom, Eric M. |
collection | PubMed |
description | HAIRY MERISTEM (HAM) proteins, members of the GRAS family of transcriptional regulators, are essential for maintenance of indeterminate growth in flowering plant shoots, loss-of-function ham mutants exhibiting a strikingly novel phenotype of shoot meristem arrest and differentiation. Specific cellular/molecular functions of HAM proteins underlying meristem maintenance are unknown. In this review, I highlight findings from recent analyses of Arabidopsis ham (Atham) loss-of-function phenotypes, including that HAM function limits the generation of clonally-derived meristem layers and that HAM function regulates CLAVATA3 expression. I consider how this new information both refines our understanding of the role of HAM proteins in regulating meristem structure and function, and may also suggest possible downstream HAM protein transcriptional targets. Finally, I note the significant phenotypic overlap between Atham phenotypes, and aintegumenta/anintegumenta-like6 double mutant phenotypes, suggesting meristem regulatory functions common to, and possible genetic interactions between, HAM and AINTEGUMENTA. |
format | Online Article Text |
id | pubmed-3405703 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Landes Bioscience |
record_format | MEDLINE/PubMed |
spelling | pubmed-34057032012-07-26 HAM proteins promote organ indeterminacy: But how? Engstrom, Eric M. Plant Signal Behav Review HAIRY MERISTEM (HAM) proteins, members of the GRAS family of transcriptional regulators, are essential for maintenance of indeterminate growth in flowering plant shoots, loss-of-function ham mutants exhibiting a strikingly novel phenotype of shoot meristem arrest and differentiation. Specific cellular/molecular functions of HAM proteins underlying meristem maintenance are unknown. In this review, I highlight findings from recent analyses of Arabidopsis ham (Atham) loss-of-function phenotypes, including that HAM function limits the generation of clonally-derived meristem layers and that HAM function regulates CLAVATA3 expression. I consider how this new information both refines our understanding of the role of HAM proteins in regulating meristem structure and function, and may also suggest possible downstream HAM protein transcriptional targets. Finally, I note the significant phenotypic overlap between Atham phenotypes, and aintegumenta/anintegumenta-like6 double mutant phenotypes, suggesting meristem regulatory functions common to, and possible genetic interactions between, HAM and AINTEGUMENTA. Landes Bioscience 2012-02-01 /pmc/articles/PMC3405703/ /pubmed/22353859 http://dx.doi.org/10.4161/psb.18958 Text en Copyright © 2012 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited. |
spellingShingle | Review Engstrom, Eric M. HAM proteins promote organ indeterminacy: But how? |
title | HAM proteins promote organ indeterminacy: But how? |
title_full | HAM proteins promote organ indeterminacy: But how? |
title_fullStr | HAM proteins promote organ indeterminacy: But how? |
title_full_unstemmed | HAM proteins promote organ indeterminacy: But how? |
title_short | HAM proteins promote organ indeterminacy: But how? |
title_sort | ham proteins promote organ indeterminacy: but how? |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3405703/ https://www.ncbi.nlm.nih.gov/pubmed/22353859 http://dx.doi.org/10.4161/psb.18958 |
work_keys_str_mv | AT engstromericm hamproteinspromoteorganindeterminacybuthow |