Histone H2A Mono-Ubiquitination Is a Crucial Step to Mediate PRC1-Dependent Repression of Developmental Genes to Maintain ES Cell Identity

Two distinct Polycomb complexes, PRC1 and PRC2, collaborate to maintain epigenetic repression of key developmental loci in embryonic stem cells (ESCs). PRC1 and PRC2 have histone modifying activities, catalyzing mono-ubiquitination of histone H2A (H2AK119u1) and trimethylation of H3 lysine 27 (H3K27...

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Detalles Bibliográficos
Autores principales: Endoh, Mitsuhiro, Endo, Takaho A., Endoh, Tamie, Isono, Kyo-ichi, Sharif, Jafar, Ohara, Osamu, Toyoda, Tetsuro, Ito, Takashi, Eskeland, Ragnhild, Bickmore, Wendy A., Vidal, Miguel, Bernstein, Bradley E., Koseki, Haruhiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3405999/
https://www.ncbi.nlm.nih.gov/pubmed/22844243
http://dx.doi.org/10.1371/journal.pgen.1002774

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3405999/
https://www.ncbi.nlm.nih.gov/pubmed/22844243
http://dx.doi.org/10.1371/journal.pgen.1002774

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