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Finding a Needle in a Haystack: The Role of Electrostatics in Target Lipid Recognition by PH Domains
Interactions between protein domains and lipid molecules play key roles in controlling cell membrane signalling and trafficking. The pleckstrin homology (PH) domain is one of the most widespread, binding specifically to phosphatidylinositol phosphates (PIPs) in cell membranes. PH domains must locate...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2012
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3406000/ https://www.ncbi.nlm.nih.gov/pubmed/22844242 http://dx.doi.org/10.1371/journal.pcbi.1002617 |