Genetic Variants in REC8, RNF212, and PRDM9 Influence Male Recombination in Cattle

We use >250,000 cross-over events identified in >10,000 bovine sperm cells to perform an extensive characterization of meiotic recombination in male cattle. We map Quantitative Trait Loci (QTL) influencing genome-wide recombination rate, genome-wide hotspot usage, and locus-specific recombinat...

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Detalles Bibliográficos
Autores principales: Sandor, Cynthia, Li, Wanbo, Coppieters, Wouter, Druet, Tom, Charlier, Carole, Georges, Michel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3406008/
https://www.ncbi.nlm.nih.gov/pubmed/22844258
http://dx.doi.org/10.1371/journal.pgen.1002854
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author Sandor, Cynthia
Li, Wanbo
Coppieters, Wouter
Druet, Tom
Charlier, Carole
Georges, Michel
author_facet Sandor, Cynthia
Li, Wanbo
Coppieters, Wouter
Druet, Tom
Charlier, Carole
Georges, Michel
author_sort Sandor, Cynthia
collection PubMed
description We use >250,000 cross-over events identified in >10,000 bovine sperm cells to perform an extensive characterization of meiotic recombination in male cattle. We map Quantitative Trait Loci (QTL) influencing genome-wide recombination rate, genome-wide hotspot usage, and locus-specific recombination rate. We fine-map three QTL and present strong evidence that genetic variants in REC8 and RNF212 influence genome-wide recombination rate, while genetic variants in PRDM9 influence genome-wide hotspot usage.
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spelling pubmed-34060082012-07-27 Genetic Variants in REC8, RNF212, and PRDM9 Influence Male Recombination in Cattle Sandor, Cynthia Li, Wanbo Coppieters, Wouter Druet, Tom Charlier, Carole Georges, Michel PLoS Genet Research Article We use >250,000 cross-over events identified in >10,000 bovine sperm cells to perform an extensive characterization of meiotic recombination in male cattle. We map Quantitative Trait Loci (QTL) influencing genome-wide recombination rate, genome-wide hotspot usage, and locus-specific recombination rate. We fine-map three QTL and present strong evidence that genetic variants in REC8 and RNF212 influence genome-wide recombination rate, while genetic variants in PRDM9 influence genome-wide hotspot usage. Public Library of Science 2012-07-26 /pmc/articles/PMC3406008/ /pubmed/22844258 http://dx.doi.org/10.1371/journal.pgen.1002854 Text en Sandor et al. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Sandor, Cynthia
Li, Wanbo
Coppieters, Wouter
Druet, Tom
Charlier, Carole
Georges, Michel
Genetic Variants in REC8, RNF212, and PRDM9 Influence Male Recombination in Cattle
title Genetic Variants in REC8, RNF212, and PRDM9 Influence Male Recombination in Cattle
title_full Genetic Variants in REC8, RNF212, and PRDM9 Influence Male Recombination in Cattle
title_fullStr Genetic Variants in REC8, RNF212, and PRDM9 Influence Male Recombination in Cattle
title_full_unstemmed Genetic Variants in REC8, RNF212, and PRDM9 Influence Male Recombination in Cattle
title_short Genetic Variants in REC8, RNF212, and PRDM9 Influence Male Recombination in Cattle
title_sort genetic variants in rec8, rnf212, and prdm9 influence male recombination in cattle
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3406008/
https://www.ncbi.nlm.nih.gov/pubmed/22844258
http://dx.doi.org/10.1371/journal.pgen.1002854
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