Identification of Tyrosine-9 of MAVS as Critical Target for Inducible Phosphorylation That Determines Activation

BACKGROUND: Innate immunity to viruses involves receptors such as RIG-I, which senses viral RNA and triggers an IFN-β signaling pathway involving the outer mitochondrial membrane protein MAVS. However, the functional status of MAVS phosphorylation remains elusive. METHODOLOGY/PRINCIPAL FINDINGS: Her...

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Detalles Bibliográficos
Autores principales: Wen, Chaoyang, Yan, Zhifeng, Yang, Xiaoli, Guan, Kai, Xu, Changzhi, Song, Ting, Zheng, Zirui, Wang, Wenjun, Wang, Ying, Zhao, Man, Zhang, Yanhong, Xu, Tao, Dou, Jianping, Liu, Jingmei, Xu, Quanbin, He, Xiang, Wei, Congwen, Zhong, Hui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3406013/
https://www.ncbi.nlm.nih.gov/pubmed/22844514
http://dx.doi.org/10.1371/journal.pone.0041687

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