Structures of Merkel Cell Polyomavirus VP1 Complexes Define a Sialic Acid Binding Site Required for Infection

The recently discovered human Merkel cell polyomavirus (MCPyV or MCV) causes the aggressive Merkel cell carcinoma (MCC) in the skin of immunocompromised individuals. Conflicting reports suggest that cellular glycans containing sialic acid (Neu5Ac) may play a role in MCPyV infectious entry. To addres...

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Detalles Bibliográficos
Autores principales: Neu, Ursula, Hengel, Holger, Blaum, Bärbel S., Schowalter, Rachel M., Macejak, Dennis, Gilbert, Michel, Wakarchuk, Warren W., Imamura, Akihiro, Ando, Hiromune, Kiso, Makoto, Arnberg, Niklas, Garcea, Robert L., Peters, Thomas, Buck, Christopher B., Stehle, Thilo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3406085/
https://www.ncbi.nlm.nih.gov/pubmed/22910713
http://dx.doi.org/10.1371/journal.ppat.1002738

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