Cargando…

Directly Infected Resting CD4+T Cells Can Produce HIV Gag without Spreading Infection in a Model of HIV Latency

Despite the effectiveness of highly active antiretroviral therapy (HAART) in treating individuals infected with HIV, HAART is not a cure. A latent reservoir, composed mainly of resting CD4+T cells, drives viral rebound once therapy is stopped. Understanding the formation and maintenance of latently...

Descripción completa

Detalles Bibliográficos
Autores principales:	Pace, Matthew J., Graf, Erin H., Agosto, Luis M., Mexas, Angela M., Male, Frances, Brady, Troy, Bushman, Frederic D., O'Doherty, Una
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3406090/ https://www.ncbi.nlm.nih.gov/pubmed/22911005 http://dx.doi.org/10.1371/journal.ppat.1002818

Ejemplares similares

Measurements of total and integrated HIV DNA demonstrate sporadic blips of unintegrated HIV DNA in HIV-positive patients on HAART
por: Mexas, A, et al.
Publicado: (2010)

Gag-Positive Reservoir Cells Are Susceptible to HIV-Specific Cytotoxic T Lymphocyte Mediated Clearance In Vitro and Can Be Detected In Vivo
por: Graf, Erin H., et al.
Publicado: (2013)

Correction: Gag-Positive Reservoir Cells Are Susceptible to HIV-Specific Cytotoxic T Lymphocyte Mediated Clearance In Vitro and Can Be Detected In Vivo
por: Graf, Erin H., et al.
Publicado: (2013)

HIV latency and integration site placement in five cell-based models
por: Sherrill-Mix, Scott, et al.
Publicado: (2013)

Elite Suppressors Harbor Low Levels of Integrated HIV DNA and High Levels of 2-LTR Circular HIV DNA Compared to HIV+ Patients On and Off HAART
por: Graf, Erin H., et al.
Publicado: (2011)

Correction: Elite Suppressors Harbor Low Levels of Integrated HIV DNA and High Levels of 2-LTR Circular HIV DNA Compared to HIV+ Patients On and Off HAART
por: Graf, Erin H., et al.
Publicado: (2011)

Quantifying integrated SIV-DNA by repetitive-sampling Alu-gag PCR
por: Mavigner, Maud, et al.
Publicado: (2016)

Naive infection predicts reservoir diversity and is a formidable hurdle to HIV eradication
por: Pinzone, Marilia R., et al.
Publicado: (2021)

Molecular mechanisms by which HERV-K Gag interferes with HIV-1 Gag assembly and particle infectivity
por: Monde, Kazuaki, et al.
Publicado: (2017)

Measuring integrated HIV DNA ex vivo and in vitro provides insights about how reservoirs are formed and maintained
por: Pinzone, Marilia Rita, et al.
Publicado: (2018)

Beyond the replication-competent HIV reservoir: transcription and translation-competent reservoirs
por: Baxter, Amy E., et al.
Publicado: (2018)

Gag-Gag Interactions Are Insufficient to Fully Stabilize and Order the Immature HIV Gag Lattice
por: Saha, Ipsita, et al.
Publicado: (2021)

FRET analysis of HIV‐1 Gag and GagPol interactions
por: Takagi, Shimon, et al.
Publicado: (2017)

Real-Time Visualization of HIV-1 GAG Trafficking in Infected Macrophages
por: Gousset, Karine, et al.
Publicado: (2008)

HIV-1 latency and virus production from unintegrated genomes following direct infection of resting CD4 T cells
por: Chan, Chi N., et al.
Publicado: (2016)

A Subset of Latency-Reversing Agents Expose HIV-Infected Resting CD4(+) T-Cells to Recognition by Cytotoxic T-Lymphocytes
por: Jones, R. Brad, et al.
Publicado: (2016)

HIV-1 Mutant Assembly, Processing and Infectivity Expresses Pol Independent of Gag
por: Yu, Fu-Hsien, et al.
Publicado: (2020)

Bioinformatics and HIV Latency
por: Ciuffi, Angela, et al.
Publicado: (2015)

Expression and reactivation of HIV in a chemokine induced model of HIV latency in primary resting CD4+ T cells
por: Saleh, Suha, et al.
Publicado: (2011)

Prospective Antiretroviral Treatment of Asymptomatic, HIV-1 Infected Controllers
por: Hatano, Hiroyu, et al.
Publicado: (2013)

Isotype Diversification of IgG Antibodies to HIV Gag Proteins as a Therapeutic Vaccination Strategy for HIV Infection
por: French, Martyn A., et al.
Publicado: (2013)

N(6)-methyladenosine of HIV-1 RNA regulates viral infection and HIV-1 Gag protein expression
por: Tirumuru, Nagaraja, et al.
Publicado: (2016)

Potential of recombinant Mycobacterium paragordonae expressing HIV-1 Gag as a prime vaccine for HIV-1 infection
por: Kim, Byoung-Jun, et al.
Publicado: (2019)

Modulation of HIV-1 Gag/Gag-Pol frameshifting by tRNA abundance
por: Korniy, Natalia, et al.
Publicado: (2019)

Effects of reduced gag cleavage efficiency on HIV-1 Gag-Pol package
por: Lin, Yi-Ru, et al.
Publicado: (2022)

Understanding Factors That Modulate the Establishment of HIV Latency in Resting CD4+ T-Cells In Vitro
por: Anderson, Jenny L., et al.
Publicado: (2016)

Insight into HIV-2 latency may disclose strategies for a cure for HIV-1 infection
por: Saleh, Suha, et al.
Publicado: (2017)

Buprenorphine Increases HIV-1 Infection In Vitro but Does Not Reactivate HIV-1 from Latency
por: Gornalusse, Germán Gustavo, et al.
Publicado: (2021)

CD4(+) and CD8(+) T Cell Activation Are Associated with HIV DNA in Resting CD4(+) T Cells
por: Cockerham, Leslie R., et al.
Publicado: (2014)

Correction: N(6)-methyladenosine of HIV-1 RNA regulates viral infection and HIV-1 Gag protein expression
por: Tirumuru, Nagaraja, et al.
Publicado: (2017)

Induction of HIV-specific T-cell responses by gag
por: Van Gulck, Ellen, et al.
Publicado: (2006)

Role of Gag in HIV Resistance to Protease Inhibitors
por: Clavel, François, et al.
Publicado: (2010)

Detection of broad functional gag-specific CD4+ T cell responses in HIV-1-infected subjects following therapeutic immunization with rMVA expressing an HIV-1 gag immunogen
por: Ondondo, Beatrice, et al.
Publicado: (2006)

The BAF complex and HIV latency
por: Mahmoudi, Tokameh
Publicado: (2012)

The role of antigen presenting cells in the induction of HIV-1 latency in resting CD4(+) T-cells
por: Kumar, Nitasha A., et al.
Publicado: (2015)

HIV Latency Is Established Directly and Early in Both Resting and Activated Primary CD4 T Cells
por: Chavez, Leonard, et al.
Publicado: (2015)

HIV-1 Latency and Latency Reversal: Does Subtype Matter?
por: Sarabia, Indra, et al.
Publicado: (2019)

Modulation of HIV-1 infectivity and cyclophilin A-dependence by Gag sequence and target cell type
por: Matsuoka, Saori, et al.
Publicado: (2009)

Timing Constraints of In Vivo Gag Mutations during Primary HIV-1 Subtype C Infection
por: Novitsky, Vladimir, et al.
Publicado: (2009)

The Effect of HLA Polymorphisms on the Recognition of Gag Epitopes in HIV-1 CRF01_AE Infection
por: Sriwanthana, Busarawan, et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_82jeo22fv9s2cpujvmte6tqg5f