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The Anti-Repressor MecR2 Promotes the Proteolysis of the mecA Repressor and Enables Optimal Expression of β-lactam Resistance in MRSA

Methicillin-resistant Staphylococcus aureus (MRSA) is an important human pathogen, which is cross-resistant to virtually all β-lactam antibiotics. MRSA strains are defined by the presence of mecA gene. The transcription of mecA can be regulated by a sensor-inducer (MecR1) and a repressor (MecI), inv...

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Detalles Bibliográficos
Autores principales:	Arêde, Pedro, Milheiriço, Catarina, de Lencastre, Hermínia, Oliveira, Duarte C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3406092/ https://www.ncbi.nlm.nih.gov/pubmed/22911052 http://dx.doi.org/10.1371/journal.ppat.1002816

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