Cargando…

MAP-Kinase Regulated Cytosolic Phospholipase A2 Activity Is Essential for Production of Infectious Hepatitis C Virus Particles

Hepatitis C virus (HCV) has infected around 160 million individuals. Current therapies have limited efficacy and are fraught with side effects. To identify cellular HCV dependency factors, possible therapeutic targets, we manipulated signaling cascades with pathway-specific inhibitors. Using this ap...

Descripción completa

Detalles Bibliográficos
Autores principales:	Menzel, Nicolas, Fischl, Wolfgang, Hueging, Kathrin, Bankwitz, Dorothea, Frentzen, Anne, Haid, Sibylle, Gentzsch, Juliane, Kaderali, Lars, Bartenschlager, Ralf, Pietschmann, Thomas
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3406102/ https://www.ncbi.nlm.nih.gov/pubmed/22911431 http://dx.doi.org/10.1371/journal.ppat.1002829

Ejemplares similares

Bile Acids Specifically Increase Hepatitis C Virus RNA-Replication
por: Chhatwal, Patrick, et al.
Publicado: (2012)

Adaptation of Hepatitis C Virus to Mouse CD81 Permits Infection of Mouse Cells in the Absence of Human Entry Factors
por: Bitzegeio, Julia, et al.
Publicado: (2010)

Hepatitis C Virus p7 is Critical for Capsid Assembly and Envelopment
por: Gentzsch, Juliane, et al.
Publicado: (2013)

Completion of Hepatitis C Virus Replication Cycle in Heterokaryons Excludes Dominant Restrictions in Human Non-liver and Mouse Liver Cell Lines
por: Frentzen, Anne, et al.
Publicado: (2011)

ABHD5/CGI-58, the Chanarin-Dorfman Syndrome Protein, Mobilises Lipid Stores for Hepatitis C Virus Production
por: Vieyres, Gabrielle, et al.
Publicado: (2016)

Entwicklungsansätze für Impfstoffe gegen Hepatitis-C-Virus-Infektionen
por: Bankwitz, Dorothea, et al.
Publicado: (2022)

Dengue Virus Non-structural Protein 1 Modulates Infectious Particle Production via Interaction with the Structural Proteins
por: Scaturro, Pietro, et al.
Publicado: (2015)

Several Human Liver Cell Expressed Apolipoproteins Complement HCV Virus Production with Varying Efficacy Conferring Differential Specific Infectivity to Released Viruses
por: Hueging, Kathrin, et al.
Publicado: (2015)

Hepatitis C Virus p7 Protein Is Crucial for Assembly and Release of Infectious Virions
por: Steinmann, Eike, et al.
Publicado: (2007)

Singapore Grouper Iridovirus Disturbed Glycerophospholipids Homeostasis: Cytosolic Phospholipase A2 Was Essential for Virus Replication
por: Ni, Na, et al.
Publicado: (2021)

Cytosolic Phospholipase A2 and Lysophospholipids in Tumor Angiogenesis
por: Linkous, Amanda G., et al.
Publicado: (2010)

Production of Infectious Genotype 1b Virus Particles in Cell Culture and Impairment by Replication Enhancing Mutations
por: Pietschmann, Thomas, et al.
Publicado: (2009)

Thiamyxins: Structure and Biosynthesis of Myxobacterial RNA‐Virus Inhibitors
por: Haack, Patrick A., et al.
Publicado: (2022)

An Essential Role of Cytosolic Phospholipase A2α in Prostaglandin E2–mediated Bone Resorption Associated with Inflammation
por: Miyaura, Chisato, et al.
Publicado: (2003)

Discrete Role for Cytosolic Phospholipase A(2)α in Platelets: Studies Using Single and Double Mutant Mice of Cytosolic and Group IIA Secretory Phospholipase A(2)
por: Wong, Dennis A., et al.
Publicado: (2002)

Essential Role of Domain III of Nonstructural Protein 5A for Hepatitis C Virus Infectious Particle Assembly
por: Appel, Nicole, et al.
Publicado: (2008)

Cytosolic Phospholipase A2 Modulates TLR2 Signaling in Synoviocytes
por: Sommerfelt, Randi M., et al.
Publicado: (2015)

Genetic Diversity Underlying the Envelope Glycoproteins of Hepatitis C Virus: Structural and Functional Consequences and the Implications for Vaccine Design
por: Tarr, Alexander W., et al.
Publicado: (2015)

Prognostic significance of cytosolic phospholipase A2 expression in patients with colorectal cancer
por: Yoo, Young Sun, et al.
Publicado: (2011)

Cytosolic phospholipase A2 regulation in the hibernating thirteen-lined ground squirrel
por: Woods, Ashley K., et al.
Publicado: (2007)

Cyclooxygenase-2 and Cytosolic Phospholipase A2 Are Overexpressed in Mucinous Pancreatic Cysts
por: Mensah, Elsie T., et al.
Publicado: (2019)

Functions and mechanisms of cytosolic phospholipase A(2) in central nervous system trauma
por: Zhang, Hao-Jie, et al.
Publicado: (2022)

A Coupled Mathematical Model of the Intracellular Replication of Dengue Virus and the Host Cell Immune Response to Infection
por: Zitzmann, Carolin, et al.
Publicado: (2020)

Hepatitis C Virus Strain-Dependent Usage of Apolipoprotein E Modulates Assembly Efficiency and Specific Infectivity of Secreted Virions
por: Weller, Romy, et al.
Publicado: (2017)

Identification of HNRNPK as Regulator of Hepatitis C Virus Particle Production
por: Poenisch, Marion, et al.
Publicado: (2015)

Cytosolic phospholipase A(2)α–deficient mice are resistant to experimental autoimmune encephalomyelitis
por: Marusic, Suzana, et al.
Publicado: (2005)

Role of Phosphorylation Sites and the C2 Domain in Regulation of Cytosolic Phospholipase A(2)
por: Gijón, Miguel A., et al.
Publicado: (1999)

Cytosolic Phospholipase A(2)α–deficient Mice Are Resistant to Collagen-induced Arthritis
por: Hegen, Martin, et al.
Publicado: (2003)

Pharmacophore-based discovery of a novel cytosolic phospholipase A(2)α inhibitor
por: Noha, Stefan M., et al.
Publicado: (2012)

Regulatory role of cytosolic phospholipase A(2) alpha in the induction of CD40 in microglia
por: Malada-Edelstein, Yafa Fetfet, et al.
Publicado: (2017)

Inhibition of Cytosolic Phospholipase A2α Induces Apoptosis in Multiple Myeloma Cells
por: Mahammad, Nur, et al.
Publicado: (2021)

Unique targeting of cytosolic phospholipase A(2) to plasma membranes mediated by the NADPH oxidase in phagocytes
por: Shmelzer, Zeev, et al.
Publicado: (2003)

Pathways Regulating Cytosolic Phospholipase A(2) Activation and Eicosanoid Production in Macrophages by Candida albicans
por: Suram, Saritha, et al.
Publicado: (2010)

Cytosolic Phospholipase A2 Regulates TNF-Induced Production of Joint Destructive Effectors in Synoviocytes
por: Sommerfelt, Randi M., et al.
Publicado: (2013)

Predominant Role of Cytosolic Phospholipase A(2)α in Dioxin-induced Neonatal Hydronephrosis in Mice
por: Yoshioka, Wataru, et al.
Publicado: (2014)

Study of the Role of Cytosolic Phospholipase A(2) Alpha in Eicosanoid Generation and Thymocyte Maturation in the Thymus
por: Rousseau, Matthieu, et al.
Publicado: (2015)

Cytosolic Phospholipase A(2) Protein as a Novel Therapeutic Target for Spinal Cord Injury
por: Liu, Nai-Kui, et al.
Publicado: (2014)

Structural basis of phosphatidylcholine recognition by the C2–domain of cytosolic phospholipase A(2)α
por: Hirano, Yoshinori, et al.
Publicado: (2019)

Physicochemical Properties Govern the Activity of Potent Antiviral Flavones
por: Martin-Benlloch, Xavier, et al.
Publicado: (2019)

The Step Further to Understand the Role of Cytosolic Phospholipase A(2) Alpha and Group X Secretory Phospholipase A(2) in Allergic Inflammation: Pilot Study
por: Pniewska, Ewa, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_v3jt3kb49m6fc65ke3bpejdk8g