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Hybrid Matrix Grafts to Favor Tissue Regeneration in Rabbit Femur Bone Lesions

At present, typical approaches employed to repair fractures and other bone lesions tend to use matrix grafts to promote tissue regeneration. These grafts act as templates, which promote cellular adhesion, growth and proliferation, osteoconduction, and even osteoinduction, which commonly results in d...

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Autores principales: Goy, Dante Pascual, Gorosito, Emmanuel, Costa, Hermes S, Mortarino, Pablo, Pedemonte, Noelia Acosta, Toledo, Javier, Mansur, Herman S, Pereira, Marivalda M, Battaglino, Ricardo, Feldman, Sara
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Bentham Open 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3406269/
https://www.ncbi.nlm.nih.gov/pubmed/22848334
http://dx.doi.org/10.2174/1874120701206010085
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author Goy, Dante Pascual
Gorosito, Emmanuel
Costa, Hermes S
Mortarino, Pablo
Pedemonte, Noelia Acosta
Toledo, Javier
Mansur, Herman S
Pereira, Marivalda M
Battaglino, Ricardo
Feldman, Sara
author_facet Goy, Dante Pascual
Gorosito, Emmanuel
Costa, Hermes S
Mortarino, Pablo
Pedemonte, Noelia Acosta
Toledo, Javier
Mansur, Herman S
Pereira, Marivalda M
Battaglino, Ricardo
Feldman, Sara
author_sort Goy, Dante Pascual
collection PubMed
description At present, typical approaches employed to repair fractures and other bone lesions tend to use matrix grafts to promote tissue regeneration. These grafts act as templates, which promote cellular adhesion, growth and proliferation, osteoconduction, and even osteoinduction, which commonly results in de novo osteogenesis. The present work aimed to study the bone-repairing ability of hybrid matrixes (HM) prepared with polyvinyl alcohol (PVA) and bioactive glass in an experimental rabbit model. The HM were prepared by combining 30% bioactive glass (nominal composition of 58% SiO2 -33 % CaO - 9% P2O5) and 70% PVA. New Zealand rabbits were randomly divided into the control group (C group) and two groups with bone lesions, in which one received a matrix implant HM (Implant group), while the other did not (no Implant group). Clinical monitoring showed no altered parameters from either the Implant or the no Implant groups as compared to the control group, for the variables of diet grades, day and night temperatures and hemograms. In the Implant group, radiologic and tomographic studies showed implanted areas with clean edges in femoral non-articular direction, and radio-dense images that suggest incipient integration. Minimum signs of phlogosis could be observed, whereas no signs of rejection at this imaging level could be identified. Histological analysis showed evidence of osteo-integration, with the formation of a trabecular bone within the implant. Together, these results show that implants of hybrid matrixes of bioactive glass are capable of promoting bone regeneration.
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spelling pubmed-34062692012-07-30 Hybrid Matrix Grafts to Favor Tissue Regeneration in Rabbit Femur Bone Lesions Goy, Dante Pascual Gorosito, Emmanuel Costa, Hermes S Mortarino, Pablo Pedemonte, Noelia Acosta Toledo, Javier Mansur, Herman S Pereira, Marivalda M Battaglino, Ricardo Feldman, Sara Open Biomed Eng J Article At present, typical approaches employed to repair fractures and other bone lesions tend to use matrix grafts to promote tissue regeneration. These grafts act as templates, which promote cellular adhesion, growth and proliferation, osteoconduction, and even osteoinduction, which commonly results in de novo osteogenesis. The present work aimed to study the bone-repairing ability of hybrid matrixes (HM) prepared with polyvinyl alcohol (PVA) and bioactive glass in an experimental rabbit model. The HM were prepared by combining 30% bioactive glass (nominal composition of 58% SiO2 -33 % CaO - 9% P2O5) and 70% PVA. New Zealand rabbits were randomly divided into the control group (C group) and two groups with bone lesions, in which one received a matrix implant HM (Implant group), while the other did not (no Implant group). Clinical monitoring showed no altered parameters from either the Implant or the no Implant groups as compared to the control group, for the variables of diet grades, day and night temperatures and hemograms. In the Implant group, radiologic and tomographic studies showed implanted areas with clean edges in femoral non-articular direction, and radio-dense images that suggest incipient integration. Minimum signs of phlogosis could be observed, whereas no signs of rejection at this imaging level could be identified. Histological analysis showed evidence of osteo-integration, with the formation of a trabecular bone within the implant. Together, these results show that implants of hybrid matrixes of bioactive glass are capable of promoting bone regeneration. Bentham Open 2012-07-10 /pmc/articles/PMC3406269/ /pubmed/22848334 http://dx.doi.org/10.2174/1874120701206010085 Text en © Goy et al.; Licensee Bentham Open. http://creativecommons.org/licenses/by-nc/3.0/ This is an open access article licensed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.
spellingShingle Article
Goy, Dante Pascual
Gorosito, Emmanuel
Costa, Hermes S
Mortarino, Pablo
Pedemonte, Noelia Acosta
Toledo, Javier
Mansur, Herman S
Pereira, Marivalda M
Battaglino, Ricardo
Feldman, Sara
Hybrid Matrix Grafts to Favor Tissue Regeneration in Rabbit Femur Bone Lesions
title Hybrid Matrix Grafts to Favor Tissue Regeneration in Rabbit Femur Bone Lesions
title_full Hybrid Matrix Grafts to Favor Tissue Regeneration in Rabbit Femur Bone Lesions
title_fullStr Hybrid Matrix Grafts to Favor Tissue Regeneration in Rabbit Femur Bone Lesions
title_full_unstemmed Hybrid Matrix Grafts to Favor Tissue Regeneration in Rabbit Femur Bone Lesions
title_short Hybrid Matrix Grafts to Favor Tissue Regeneration in Rabbit Femur Bone Lesions
title_sort hybrid matrix grafts to favor tissue regeneration in rabbit femur bone lesions
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3406269/
https://www.ncbi.nlm.nih.gov/pubmed/22848334
http://dx.doi.org/10.2174/1874120701206010085
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