Cargando…
Genomic evolution in Barrett’s adenocarcinoma cells: critical roles of elevated hsRAD51, homologous recombination and Alu sequences in the genome
A prominent feature of most cancers including Barrett’s adenocarcinoma (BAC) is genetic instability, which is associated with development and progression of disease. In this study, we investigated the role of recombinase (hsRAD51), a key component of homologous recombination (HR)/repair, in evolving...
Autores principales: | Pal, J, Bertheau, R, Buon, L, Qazi, A, Batchu, RB, Bandyopadhyay, S, Ali-Fehmi, R, Beer, DG, Weaver, DW, Reis, RJ Shmookler, Goyal, RK, Huang, Q, Munshi, NC, Shammas, MA |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2011
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3406293/ https://www.ncbi.nlm.nih.gov/pubmed/21423218 http://dx.doi.org/10.1038/onc.2011.83 |
Ejemplares similares
-
Dynamic unwrapping of nucleosomes by HsRAD51 that includes sliding and rotational motion of histone octamers
por: Senavirathne, Gayan, et al.
Publicado: (2017) -
Impact of RAD51C-mediated Homologous Recombination on Genomic
Integrity in Barrett’s Adenocarcinoma Cells
por: Pal, Jagannath, et al.
Publicado: (2017) -
Telomerase inhibition by siRNA causes senescence and apoptosis in Barrett's adenocarcinoma cells: mechanism and therapeutic potential
por: Shammas, Masood A, et al.
Publicado: (2005) -
Targeting homologous recombination and telomerase in Barrett’s adenocarcinoma: Impact on telomere maintenance, genomic instability, and tumor growth
por: Lu, Renquan, et al.
Publicado: (2013) -
Alu pair exclusions in the human genome
por: Cook, George W, et al.
Publicado: (2011)