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Recoupling the Cardiac Nitric Oxide Synthases: Tetrahydrobiopterin Synthesis and Recycling

Nitric oxide (NO), a key regulator of cardiovascular function, is synthesized from L-arginine and oxygen by the enzyme nitric oxide synthase (NOS). This reaction requires tetrahydrobiopterin (BH4) as a cofactor. BH4 is synthesized from guanosine triphosphate (GTP) by GTP cyclohydrolase I (GTPCH) and...

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Detalles Bibliográficos
Autores principales:	Alkaitis, Matthew S., Crabtree, Mark J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Current Science Inc. 2012
Materias:	Investigative Therapies (J.-L. Balligand, Section editor)
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3406312/ https://www.ncbi.nlm.nih.gov/pubmed/22711313 http://dx.doi.org/10.1007/s11897-012-0097-5

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