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Ceramide mediates nanovesicle shedding and cell death in response to phosphatidylinositol ether lipid analogs and perifosine

Anticancer phospholipids that inhibit Akt such as the alkylphospholipid perifosine (Per) and phosphatidylinositol ether lipid analogs (PIAs) promote cellular detachment and apoptosis and have a similar cytotoxicity profile against cancer cell lines in the NCI60 panel. While investigating the mechani...

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Detalles Bibliográficos
Autores principales:	Gills, J J, Zhang, C, Abu-Asab, M S, Castillo, S S, Marceau, C, LoPiccolo, J, Kozikowski, A P, Tsokos, M, Goldkorn, T, Dennis, P A
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2012
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3406576/ https://www.ncbi.nlm.nih.gov/pubmed/22764099 http://dx.doi.org/10.1038/cddis.2012.72

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