Granzyme B triggers a prolonged pressure to die in Bcl-2 overexpressing cells, defining a window of opportunity for effective treatment with ABT-737

Overexpression of Bcl-2 contributes to resistance of cancer cells to human cytotoxic lymphocytes (CL) by blocking granzyme B (GraB)-induced mitochondrial outer membrane permeabilization (MOMP). Drugs that neutralise Bcl-2 (e.g., ABT-737) may therefore be effective adjuvants for immunotherapeutic str...

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Detalles Bibliográficos
Autores principales: Sutton, V R, Sedelies, K, Dewson, G, Christensen, M E, Bird, P I, Johnstone, R W, Kluck, R M, Trapani, J A, Waterhouse, N J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2012
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3406577/
https://www.ncbi.nlm.nih.gov/pubmed/22764103
http://dx.doi.org/10.1038/cddis.2012.73

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