Low molecular weight, non-peptidic agonists of TrkA receptor with NGF-mimetic activity

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Exploitation of the biologic activity of neurotrophins is desirable for medical purposes, but their protein nature intrinsically bears adverse pharmacokinetic properties. Here, we report synthesis and biologic characterization of a novel class of low molecular weight, non-peptidic compounds with NGF...

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Detalles Bibliográficos
Autores principales: Scarpi, D, Cirelli, D, Matrone, C, Castronovo, G, Rosini, P, Occhiato, E G, Romano, F, Bartali, L, Clemente, A M, Bottegoni, G, Cavalli, A, De Chiara, G, Bonini, P, Calissano, P, Palamara, A T, Garaci, E, Torcia, M G, Guarna, A, Cozzolino, F
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2012
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3406579/
https://www.ncbi.nlm.nih.gov/pubmed/22764098
http://dx.doi.org/10.1038/cddis.2012.80

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