Fission Yeast Dma1 Requires RING Domain Dimerization for Its Ubiquitin Ligase Activity and Mitotic Checkpoint Function

In fission yeast (Schizosaccharomyces pombe), the E3 ubiquitin ligase Dma1 delays cytokinesis if chromosomes are not properly attached to the mitotic spindle. Dma1 contains a C-terminal RING domain, and we have found that the Dma1 RING domain forms a stable homodimer. Although the RING domain is req...

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Detalles Bibliográficos
Autores principales: Johnson, Alyssa E., Collier, Scott E., Ohi, Melanie D., Gould, Kathleen L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2012
Materias:
Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3406662/
https://www.ncbi.nlm.nih.gov/pubmed/22669973
http://dx.doi.org/10.1074/jbc.M112.349712

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3406662/
https://www.ncbi.nlm.nih.gov/pubmed/22669973
http://dx.doi.org/10.1074/jbc.M112.349712

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