Clinical relevance of systematic human papillomavirus (HPV) diagnosis in oral squamous cell carcinoma

Head & Neck Cancer (HNC) is one of the most common malignancies worldwide and among oral neoplasias about 90-92% are squamous cell carcinomas (OSCC). Alcohol and tobacco consumption have been recognized as the main risk factors for development of OSCC. However, 10 to 20% of patients suffering fr...

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Autores principales: Bertolus, Chloé, Goudot, Patrick, Gessain, Antoine, Berthet, Nicolas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3406976/
https://www.ncbi.nlm.nih.gov/pubmed/22647139
http://dx.doi.org/10.1186/1750-9378-7-13
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author Bertolus, Chloé
Goudot, Patrick
Gessain, Antoine
Berthet, Nicolas
author_facet Bertolus, Chloé
Goudot, Patrick
Gessain, Antoine
Berthet, Nicolas
author_sort Bertolus, Chloé
collection PubMed
description Head & Neck Cancer (HNC) is one of the most common malignancies worldwide and among oral neoplasias about 90-92% are squamous cell carcinomas (OSCC). Alcohol and tobacco consumption have been recognized as the main risk factors for development of OSCC. However, 10 to 20% of patients suffering from OSCC have no history of use of these substances. Clinico-pathological evidence suggests that we are dealing with virally-induced cancers, and that HPV should not be a relevant candidate. A systematic search of HPV in OSCC has no real relevance in current clinical practice even although it is still relevant in organized research protocols. Further studies are ongoing, with the aim of identifying other infectious agents, including viruses, in OSCC.
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spelling pubmed-34069762012-07-28 Clinical relevance of systematic human papillomavirus (HPV) diagnosis in oral squamous cell carcinoma Bertolus, Chloé Goudot, Patrick Gessain, Antoine Berthet, Nicolas Infect Agent Cancer Commentary Head & Neck Cancer (HNC) is one of the most common malignancies worldwide and among oral neoplasias about 90-92% are squamous cell carcinomas (OSCC). Alcohol and tobacco consumption have been recognized as the main risk factors for development of OSCC. However, 10 to 20% of patients suffering from OSCC have no history of use of these substances. Clinico-pathological evidence suggests that we are dealing with virally-induced cancers, and that HPV should not be a relevant candidate. A systematic search of HPV in OSCC has no real relevance in current clinical practice even although it is still relevant in organized research protocols. Further studies are ongoing, with the aim of identifying other infectious agents, including viruses, in OSCC. BioMed Central 2012-05-30 /pmc/articles/PMC3406976/ /pubmed/22647139 http://dx.doi.org/10.1186/1750-9378-7-13 Text en Copyright ©2012 Bertolus et al. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Commentary
Bertolus, Chloé
Goudot, Patrick
Gessain, Antoine
Berthet, Nicolas
Clinical relevance of systematic human papillomavirus (HPV) diagnosis in oral squamous cell carcinoma
title Clinical relevance of systematic human papillomavirus (HPV) diagnosis in oral squamous cell carcinoma
title_full Clinical relevance of systematic human papillomavirus (HPV) diagnosis in oral squamous cell carcinoma
title_fullStr Clinical relevance of systematic human papillomavirus (HPV) diagnosis in oral squamous cell carcinoma
title_full_unstemmed Clinical relevance of systematic human papillomavirus (HPV) diagnosis in oral squamous cell carcinoma
title_short Clinical relevance of systematic human papillomavirus (HPV) diagnosis in oral squamous cell carcinoma
title_sort clinical relevance of systematic human papillomavirus (hpv) diagnosis in oral squamous cell carcinoma
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3406976/
https://www.ncbi.nlm.nih.gov/pubmed/22647139
http://dx.doi.org/10.1186/1750-9378-7-13
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