Cargando…

The balance between two isoforms of LEF-1 regulates colon carcinoma growth

BACKGROUND: Colon cancer is one of the most aggressive human malignancies, with a very poor prognosis. Although it has been suggested that different isoforms of the lymphoid enhancer factor (LEF-1) have opposing biological activities, the biological outcome of aberrant LEF-1 activation in colon canc...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wang, Shu-Hong, Nan, Ke-Jun, Wang, Yao-Chun, Wang, Wen-Juan, Tian, Tao
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3407021/ https://www.ncbi.nlm.nih.gov/pubmed/22639890 http://dx.doi.org/10.1186/1471-230X-12-53

Ejemplares similares

LEF1 isoforms regulate cellular senescence and aging
por: Jia, Minxue, et al.
Publicado: (2023)

Increased LEF1 Expression and Decreased Notch2 Expression Are Strong Predictors of Poor Outcomes in Colorectal Cancer Patients
por: Wang, Wen-Juan, et al.
Publicado: (2013)

Cinobufagin Suppresses Melanoma Cell Growth by Inhibiting LEF1
por: Kim, Geon-Hee, et al.
Publicado: (2020)

CRISPR/Cas9-Mediated Disruption of the lef8 and lef9 to Inhibit Nucleopolyhedrovirus Replication in Silkworms
por: Liu, Yujia, et al.
Publicado: (2022)

The transcription factor LEF1 interacts with NFIX and switches isoforms during adult hippocampal neural stem cell quiescence
por: García-Corzo, Laura, et al.
Publicado: (2022)

LEF1 Enhances the Progression of Colonic Adenocarcinoma via Remodeling the Cell Motility Associated Structures
por: Xiao, Li, et al.
Publicado: (2021)

Liver cancer: WISP3 suppresses hepatocellular carcinoma progression by negative regulation of β‐catenin/TCF/LEF signalling
por: Gao, Hong, et al.
Publicado: (2019)

Overexpression of the Insulin Receptor Isoform A Promotes Endometrial Carcinoma Cell Growth
por: Wang, Chun-Fang, et al.
Publicado: (2013)

Expression of AKR1C3, β-Catenin and LEF1 in Esophageal Squamous Cell Carcinoma and the Relationship with Radiation Resistance
por: Xiong, Wei, et al.
Publicado: (2021)

A role for YY1 in repression of dominant negative LEF-1 expression in colon cancer
por: Yokoyama, Noriko N., et al.
Publicado: (2010)

Inhibition of canonical WNT/β-catenin signaling is involved in leflunomide (LEF)-mediated cytotoxic effects on renal carcinoma cells
por: Chen, Yicheng, et al.
Publicado: (2016)

LEF-1 Regulates Tyrosinase Gene Transcription In Vitro
por: Wang, Xueping, et al.
Publicado: (2015)

LEF1-AS1, a long-noncoding RNA, promotes malignancy in glioblastoma
por: Wang, Jin, et al.
Publicado: (2017)

Groucho binds two conserved regions of LEF-1 for HDAC-dependent repression
por: Arce, Laura, et al.
Publicado: (2009)

Oligomerization of Baculovirus LEF-11 Is Involved in Viral DNA Replication
por: Dong, Zhan-Qi, et al.
Publicado: (2015)

Function of LEF1 in early mammary development
por: Kratochwil, K, et al.
Publicado: (2003)

Lef1 restricts ectopic crypt formation and tumor cell growth in intestinal adenomas
por: Heino, Sarika, et al.
Publicado: (2021)

LEF1/Id3/HRAS axis promotes the tumorigenesis and progression of esophageal squamous cell carcinoma
por: Wang, Xinyu, et al.
Publicado: (2020)

FOXP4 promotes laryngeal squamous cell carcinoma progression through directly targeting LEF-1
por: Shi, Jian, et al.
Publicado: (2021)

LEF1 enhances β-catenin transactivation through IDR-dependent liquid–liquid phase separation
por: Zhao, Bing, et al.
Publicado: (2023)

Oct4 induces EMT through LEF1/β-catenin dependent WNT signaling pathway in hepatocellular carcinoma
por: Sun, Lu, et al.
Publicado: (2017)

LSD1 Promotes Bladder Cancer Progression by Upregulating LEF1 and Enhancing EMT
por: Xie, Qiubo, et al.
Publicado: (2020)

CHIP promotes Wnt signaling and regulates Arc stability by recruiting and polyubiquitinating LEF1 or Arc
por: Liu, Yuchun, et al.
Publicado: (2021)

The Role of LEF1 in Endometrial Gland Formation and Carcinogenesis
por: Shelton, Dawne N., et al.
Publicado: (2012)

Normative data for the lower extremity functional scale (LEFS)
por: Dingemans, Siem A, et al.
Publicado: (2017)

Lef1-dependent hypothalamic neurogenesis inhibits anxiety
por: Xie, Yuanyuan, et al.
Publicado: (2017)

The transcription factor LEF1 promotes tumorigenicity and activates the TGF-β signaling pathway in esophageal squamous cell carcinoma
por: Zhao, Yue, et al.
Publicado: (2019)

Aggregation of AcMNPV LEF-10 and Its Impact on Viral Late Gene Expression
por: Xu, Xiaodong, et al.
Publicado: (2016)

Domain-specific regulation of foxP2 CNS expression by lef1
por: Bonkowsky, Joshua L, et al.
Publicado: (2008)

An alternative polyadenylation signal in TCF7L2 generates isoforms that inhibit T cell factor/lymphoid-enhancer factor (TCF/LEF)-dependent target genes
por: Locke, J. M., et al.
Publicado: (2011)

Postnatal isoform switch and protein localization of LEF1 and TCF7L2 transcription factors in cortical, thalamic, and mesencephalic regions of the adult mouse brain
por: Nagalski, A., et al.
Publicado: (2012)

Lateral confined growth of cells activates Lef1 dependent pathways to regulate cell-state transitions
por: Yuan, Luezhen, et al.
Publicado: (2022)

Knockdown of Lymphoid Enhancer factor 1 Inhibits Colon Cancer Progression In Vitro and In Vivo
por: Wang, Wen-Juan, et al.
Publicado: (2013)

Role of TCF/LEF Transcription Factors in Bone Development and Osteogenesis
por: Li, Zhengqiang, et al.
Publicado: (2018)

TCF/LEF Transcription Factors: An Update from the Internet Resources
por: Hrckulak, Dusan, et al.
Publicado: (2016)

Met lef tegen de waan van de dag
por: Tax, Sandra
Publicado: (2022)

Lef1 Contributes to the Differentiation of Bulge Stem Cells by Nuclear Translocation and Cross-Talk with the Notch Signaling Pathway
por: Zhang, Yi, et al.
Publicado: (2013)

Long Non-Coding RNA LEF1-AS1 Promotes Migration, Invasion and Metastasis of Colon Cancer Cells Through miR-30-5p/SOX9 Axis
por: Sun, Ting, et al.
Publicado: (2020)

β1 integrin-mediated multicellular resistance in hepatocellular carcinoma through activation of the FAK/Akt pathway
por: Tian, Tao, et al.
Publicado: (2018)

Carcinogenesis promotion in oral squamous cell carcinoma: KDM4A complex-mediated gene transcriptional suppression by LEF1
por: Hou, Yiming, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_3rvl1gd6itp488aaf3nvq50je2