Therapeutic Inhibition of Pro-Inflammatory Signaling and Toxicity to Staphylococcal Enterotoxin B by a Synthetic Dimeric BB-Loop Mimetic of MyD88

Staphylococcal enterotoxin B (SEB) exposure triggers an exaggerated pro-inflammatory cytokine response that often leads to toxic shock syndrome (TSS) associated with organ failure and death. MyD88 mediates pro-inflammatory cytokine signaling induced by SEB exposure and MyD88(−/−) mice are resistant...

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Detalles Bibliográficos
Autores principales: Kissner, Teri L., Ruthel, Gordon, Alam, Shahabuddin, Mann, Enrique, Ajami, Dariush, Rebek, Mitra, Larkin, Eileen, Fernandez, Stefan, Ulrich, Robert G., Ping, Sun, Waugh, David S., Rebek, Julius, Saikh, Kamal U.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3407147/
https://www.ncbi.nlm.nih.gov/pubmed/22848400
http://dx.doi.org/10.1371/journal.pone.0040773

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