An NQO1-Initiated and p53-Independent Apoptotic Pathway Determines the Anti-Tumor Effect of Tanshinone IIA against Non-Small Cell Lung Cancer

NQO1 is an emerging and promising therapeutic target in cancer therapy. This study was to determine whether the anti-tumor effect of tanshinone IIA (TSA) is NQO1 dependent and to elucidate the underlying apoptotic cell death pathways. NQO1(+) A549 cells and isogenically matched NQO1 transfected and...

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Detalles Bibliográficos
Autores principales: Liu, Fang, Yu, Guo, Wang, Guangji, Liu, Huiying, Wu, Xiaolan, Wang, Qiong, Liu, Miao, Liao, Ke, Wu, Mengqiu, Cheng, Xuefang, Hao, Haiping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3407158/
https://www.ncbi.nlm.nih.gov/pubmed/22848731
http://dx.doi.org/10.1371/journal.pone.0042138

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3407158/
https://www.ncbi.nlm.nih.gov/pubmed/22848731
http://dx.doi.org/10.1371/journal.pone.0042138

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