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Deletion of the Innate Immune NLRP3 Receptor Abolishes Cardiac Ischemic Preconditioning and Is Associated with Decreased Il-6/STAT3 Signaling

OBJECTIVE: Recent studies indicate that the innate immune system is not only triggered by exogenous pathogens and pollutants, but also by endogenous danger signals released during ischemia and necrosis. As triggers for the innate immune NLRP3 inflammasome protein complex appear to overlap with those...

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Detalles Bibliográficos
Autores principales:	Zuurbier, Coert J., Jong, Willeke M. C., Eerbeek, Otto, Koeman, Anneke, Pulskens, Wilco P., Butter, Loes M., Leemans, Jaklien C., Hollmann, Markus W.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3407219/ https://www.ncbi.nlm.nih.gov/pubmed/22848390 http://dx.doi.org/10.1371/journal.pone.0040643

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