Cargando…
Experimental in vivo and in vitro treatment with a new histone deacetylase inhibitor belinostat inhibits the growth of pancreatic cancer
BACKGROUND: Treatment options for pancreatic ductal adenocarcinoma (PDAC) are limited. Histone deacetylase inhibitors are a new and promising drug family with strong anticancer activity. The aim of this study was to examine the efficacy of in vitro and in vivo treatment with the novel pan-HDAC inhib...
Autores principales: | Dovzhanskiy, Dmitriy I, Arnold, Stefanie M, Hackert, Thilo, Oehme, Ina, Witt, Olaf, Felix, Klaus, Giese, Nathalia, Werner, Jens |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2012
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3407493/ https://www.ncbi.nlm.nih.gov/pubmed/22681698 http://dx.doi.org/10.1186/1471-2407-12-226 |
Ejemplares similares
-
The histone deacetylase inhibitor belinostat (PXD101) suppresses bladder cancer cell growth in vitro and in vivo
por: Buckley, Michael T, et al.
Publicado: (2007) -
The enzyme activity of histone deacetylase 8 is modulated by a redox-switch
por: Jänsch, Niklas, et al.
Publicado: (2018) -
Mutant Isocitrate Dehydrogenase 1 Expression Enhances Response of Gliomas to the Histone Deacetylase Inhibitor Belinostat
por: Chang, Chi-Ming, et al.
Publicado: (2023) -
Objective parameters aid the prediction of fistulas in pancreatic surgery
por: FELIX, KLAUS, et al.
Publicado: (2014) -
Differential effects of class I isoform histone deacetylase depletion and enzymatic inhibition by belinostat or valproic acid in HeLa cells
por: Dejligbjerg, Marielle, et al.
Publicado: (2008)