Penetration of anticancer drugs through tumour tissue as a function of cellular packing density and interstitial fluid pressure and its modification by bortezomib

BACKGROUND: Limited penetration of anticancer drugs in solid tumours is a probable cause of drug resistance. Our previous results indicate that drug penetration depends on cellular packing density and adhesion between cancer cells. METHODS: We used epithelioid and round cell variants of the HCT-8 hu...

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Detalles Bibliográficos
Autores principales: Grantab, Rama H, Tannock, Ian F
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3407510/
https://www.ncbi.nlm.nih.gov/pubmed/22672469
http://dx.doi.org/10.1186/1471-2407-12-214

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3407510/
https://www.ncbi.nlm.nih.gov/pubmed/22672469
http://dx.doi.org/10.1186/1471-2407-12-214

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