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Penetration of anticancer drugs through tumour tissue as a function of cellular packing density and interstitial fluid pressure and its modification by bortezomib
BACKGROUND: Limited penetration of anticancer drugs in solid tumours is a probable cause of drug resistance. Our previous results indicate that drug penetration depends on cellular packing density and adhesion between cancer cells. METHODS: We used epithelioid and round cell variants of the HCT-8 hu...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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BioMed Central
2012
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3407510/ https://www.ncbi.nlm.nih.gov/pubmed/22672469 http://dx.doi.org/10.1186/1471-2407-12-214 |